論文一覧 | 単離心臓・培養心筋細胞 | 膜電位感受性色素
sakuraba単離心臓（ランゲンドルフ灌流心）
合計：244
| 論文名 | サンプル | 色素 | イメージングシステム |
|---|---|---|---|
| Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes. Duanyang Xie, Ke Xiong, Xuling Su, Guanghua Wang, Qiang Ji, Qicheng Zou, Lingling Wang, Yi Liu, Dandan Liang, Jinfeng Xue, Luxin Wang, Xueting Gao, Xingdong Gu, Hongyu Liu, Xiaoyu He, Li Li, Jian Yang, Youming Lu, Luying Peng & Yi-Han Chen Cell Research volume 31, pages951?964 (2021) | Isolated heart | VSD (RH-237) | MiCAM ULTIMA |
| α1-adrenergic stimulation increases ventricular action potential duration in the intact mouse heart. William Joyce, Koen T. Scholman, Bjarke Jensen, Tobias Wang, and Bastiaan J. Boukens FACETS. 6(): 823-836. | Isolated heart | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Proinflammatory Cytokine Modulates Intracellular Calcium Handling and Enhances Ventricular Arrhythmia Susceptibility. Yung-Nan Tsai, Ya-Wen Hsiao, Shien-Fong Lin, Yi-Hsin Chan, Yu-Cheng Hsieh, Wei-Hua Tang, An-Sheng Lee, Yu-Ting Huang, Hsing-Yuan Li, Tze-Fan Chao, Satoshi Higa, Tsu-Juey Wu, Shih-Lin Chang, Shih-Ann Chen Front Cardiovasc Med. 2021 Mar 16;8:623510. | Isolated heart | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM02 (dual camera) |
| Adult zebrafish ventricular electrical gradients as tissue mechanisms of ECG patterns under baseline vs. oxidative stress. Yali Zhao, Nicholas A James, Ashraf R Beshay, Eileen E Chang, Andrew Lin, Faiza Bashar, Abram Wassily, Binh Nguyen, Thao P Nguyen Cardiovasc Res. 2021 Jul 7;117(8):1891-1907. | Isolated heart (zebrafish) | VSD (Di-4-ANEPPS) | MiCAM03 |
| Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models. Fumin Fu, Michael Pietropaolo, Lei Cui, Shilpa Pandit, Weiyan Li, Oleg Tarnavski, Suraj S. Shetty, Jing Liu, Jennifer M. Lussier, Yutaka Murakami, Prabhjit K. Grewal, Galina Deyneko, Gordon M. Turner, Andrew K.P. Taggart, M. Gerard Waters, Shaun Coughlin, Yuichiro Adachi bioRxiv 2021.08.17.456655; | Isolated heart | VSD (Di-4-ANEPPS) | MiCAM03 |
| High Level of Real Urban Air Pollution Promotes Cardiac Arrhythmia in Healthy Mice. Hyewon Park, Sangchul Lim, Seunghoon Lee, Dasom Mun, JiYoung Kang, Hyoeun Kim, Hyelim Park, Changsoo Kim, Sunho Park, Yeong Min Lim, Boyoung Joung Korean Circ J. 2021 Feb;51(2):157-170. | Isolated heart | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Adherens junction engagement regulates functional patterning of the cardiac pacemaker cell lineage. Kandace Thomas, Trevor Henley, Simone Rossi, M Joseph Costello, William Polacheck, Boyce E Griffith, Michael Bressan Dev Cell. 2021 May 17;56(10):1498-1511.e7. | Isolated heart (chick embryo) | VSD (Di-4-ANEPPS) CaSD (Cal-520) | MiCAM ULTIMA |
| Theoretical Models and Computational Analysis of Action Potential Dispersion for Cardiac Arrhythmia Risk Stratification. Uma Mahesh R. Avula, Lea Melki, Jared S. Kushner, Stephanie Liang, and Elaine Y. Wan Front Cardiovasc Med. 2021; 8: 649489. | Isolated heart | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Role of Reduced Sarco-Endoplasmic Reticulum Ca2+-ATPase Function on Sarcoplasmic Reticulum Ca2+ Alternans in the Intact Rabbit Heart. Lianguo Wang, Rachel C. Myles, I-Ju Lee, Donald M. Bers, and Crystal M. Ripplinger Front Physiol. 2021; 12: 656516. | Isolated heart | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Fully implantable and bioresorbable cardiac pacemakers without leads or batteries. Yeon Sik Choi, Rose T Yin, Anna Pfenniger, Jahyun Koo, Raudel Avila, K Benjamin Lee, Sheena W Chen, Geumbee Lee, Gang Li, Yun Qiao, Alejandro Murillo-Berlioz, Alexi Kiss, Shuling Han, Seung Min Lee, Chenhang Li, Zhaoqian Xie, Yu-Yu Chen, Amy Burrell, Beth Geist, Hyoyoung Jeong, Joohee Kim, Hong-Joon Yoon, Anthony Banks, Seung-Kyun Kang, Zheng Jenny Zhang, Chad R Haney, Alan Varteres Sahakian, David Johnson, Tatiana Efimova, Yonggang Huang, Gregory D Trachiotis, Bradley P Knight, Rishi K Arora, Igor R Efimov, John A Rogers Nat Biotechnol. 2021 Jun 28. | Isolated heart | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Flexible and Transparent Metal Nanowire Microelectrode Arrays and Interconnects for Electrophysiology, Optogenetics, and Optical Mapping. Zhiyuan Chen, Nicolas Boyajian, Zexu Lin, Rose T. Yin, Sofian N. Obaid, Jinbi Tian, Jaclyn A. Brennan, Sheena W. Chen, Alana N. Miniovich, Leqi Lin, Yarong Qi, Xitong Liu, Igor R. Efimov, Luyao Lu Adv. Mater. Technol. 2021, 6, 2100225. | Isolated heart | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Rutaecarpine targets hERG channels and participates in regulating electrophysiological properties leading to ventricular arrhythmia. Ge Zhan, Fang Wang, Yun-qi Ding, Xiang-hua Li, Yue-xin Li, Zheng-rong Zhao, Jia-xin Li, Yan Liu, Xin Zhao, Cai-chuan Yan, Bao-xin Li J Cell Mol Med. 2021;00:1?12. | Isolated heart | VSD (RH-237) | MiCAM05 |
| Knockout of interleukin-17A diminishes ventricular arrhythmia susceptibility in diabetic mice via inhibiting NF-κB-mediated electrical remodeling. De-sheng Li, Gen-long Xue, Ji-ming Yang, Chang-zhu Li, Rui-xin Zhang, Tao Tian, Zheng Li, Ke-wei Shen, Yang Guo, Xue-ning Liu, Jin Wang, Yan-jie Lu & Zhen-wei Pan Acta Pharmacologica Sinica (2021) | Isolated heart | VSD (RH-237) | MiCAM05 |
| Anti-arrhythmic and inotropic effects of empagliflozin following myocardial ischemia. Mohammed Ali Azam, Praloy Chakraborty, Daoyuan Si, BeiBei Du, Stéphane Massé, Patrick F H Lai, Andrew C T Ha, Kumaraswamy Nanthakumar Life Sci. 2021 Jul 1;276:119440. | Isolated heart | CaSD (Rhod-2 AM) | MiCAM ULTIMA |
| NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias. Larry Scott Jr, Anke C Fender, Arnela Saljic, Luge Li, Xiaohui Chen, Xiaolei Wang, Dominik Linz, Jilu Lang, Mathias Hohl, Darragh Twomey, Thuy T Pham, Rodrigo Diaz-Lankenau, Mihail G Chelu, Markus Kamler, Mark L Entman, George E Taffet, Prashanthan Sanders, Dobromir Dobrev, Na Li Cardiovasc Res. 2021 Jun 16;117(7):1746-1759. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Minimally invasive system to reliably characterize ventricular electrophysiology from living donors. Aida Oliván-Viguera, María Pérez-Zabalza, Laura García-Mendívil, Konstantinos A. Mountris, Sofía Orós-Rodrigo, Estel Ramos-Marquès, José María Vallejo-Gil, Pedro Carlos Fresneda-Roldán, Javier Fañanás-Mastral, Manuel Vázquez-Sancho, Marta Matamala-Adell, Fernando Sorribas-Berjón, Javier André Bellido-Morales, Francisco Javier Mancebón-Sierra, Alexánder Sebastián Vaca-Núñez, Carlos Ballester-Cuenca, Miguel Ángel Marigil, Cristina Pastor, Laura Ordovás, Ralf Köhler, Emiliano Diez & Esther Pueyo Scientific Reports volume 10, Article number: 19941 (2020). | Tissue slice (human) | VSD (RH-237) | MiCAM05 |
| Thioridazine Induces Cardiotoxicity via Reactive Oxygen Species-Mediated hERG Channel Deficiency and L-Type Calcium Channel Activation. Yan Liu, Xueqi Xu, Yuhao Zhang, Mingzhu Li, Jiamengyi Guo, Caichuan Yan, Fang Wang, Yuexin Li, Yunqi Ding, Baoxin Li, and Pan Fan Oxidative Medicine and Cellular Longevity, vol. 2020, Article ID 3690123, 17 pages, 2020. | Isolated heart (mouse) | VSD (RH-237) | MiCAM ULTIMA |
| Identification of transmembrane protein 168 mutation in familial Brugada syndrome. Akio Shimizu, Dimitar P Zankov, Akira Sato, Masahiro Komeno, Futoshi Toyoda, Satoru Yamazaki, Toshinori Makita, Taichi Noda, Masahito Ikawa, Yoshihiro Asano, Yohei Miyashita, Seiji Takashima, Hiroshi Morita, Taisuke Ishikawa, Naomasa Makita, Masahito Hitosugi, Hiroshi Matsuura, Seiko Ohno, Minoru Horie, Hisakazu Ogita FASEB J. 2020 May;34(5):6399-6417. | Isolated heart (mouse) | VSD (RH-237) | MiCAM03 |
| Innervation and Neuronal Control of the Mammalian Sinoatrial Node: A Comprehensive Atlas. Peter Hanna, Michael J. Dacey, Jaclyn Brennan, Alison Moss, Shaina Robbins, Sirisha Achanta, Natalia P. Biscola, Mohammed A. Swid, Pradeep S. Rajendran, Shumpei Mori, Joseph E. Hadaya, Elizabeth H. Smith, Stanley G. Peirce, Jin Chen, Leif A. Havton, Zixi (Jack) Cheng, Rajanikanth Vadigepalli, James Schwaber, Robert L. Lux, Igor Efimov, John D. Tompkins, Donald B. Hoover, Jeffrey L. Ardell, Kalyanam Shivkumar bioRxiv 2020.10.28.359109. | SAN/atria preparation (human) | VSD (Di-4-ANEPPS) | MiCAM05 |
| Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding?deficient channels. Jeffrey Abrams, Daniel Roybal, Nourdine Chakouri, Alexander N. Katchman, Richard Weinberg, Lin Yang, Bi-xing Chen, Sergey I. Zakharov, Jessica A. Hennessey, Uma Mahesh R. Avula, Johanna Diaz, Chaojian Wang, Elaine Y. Wan, Geoffrey S. Pitt, Manu Ben-Johny, and Steven O. Marx JCI Insight. 2020 Oct 2; 5(19): e141736. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells. Stefanie Fenske, Konstantin Hennis, René D. Rötzer, Verena F. Brox, Elvir Becirovic, Andreas Scharr, Christian Gruner, Tilman Ziegler, Verena Mehlfeld, Jaclyn Brennan, Igor R. Efimov, Audrys G. Pauža, Markus Moser, Carsten T. Wotjak, Christian Kupatt, Rasmus Gönner, Rai Zhang, Henggui Zhang, Xiangang Zong, Martin Biel and Christian Wahl-Schott Nat Commun. 2020; 11: 5555. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM05 |
| The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unresponsive to standard heart failure therapy. Tim R. Eijgenraam, Bastiaan J. Boukens, Cornelis J. Boogerd, E. Marloes Schouten, Cees W. A. van de Kolk, Nienke M. Stege, Wouter P. te Rijdt, Edgar T. Hoorntje, Paul A. van der Zwaag, Eva van Rooij, J. Peter van Tintelen, Maarten P. van den Berg, Peter van der Meer, Jolanda van der Velden, Herman H. W. Silljé & Rudolf A. de Boer Scientific Reports volume 10, Article number: 9819 (2020) | Isolated heart (mouse) | VSD (RH-237) | MiCAM05 |
| Anti-Inflammatory and Antiarrhythmic Effects of Beta Blocker in a Rat Model of Rheumatoid Arthritis. Ting-Tse Lin, Yen-Ling Sung, Jhen-Yang Syu, Kia-Yuan Lin, Hung-Jui Hsu, Min-Tsun Liao, Yen-Bin Liu, Shien-Fong Lin J Am Heart Assoc. 2020 Sep 15;9(18):e016084. | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Acute Effects of Ibrutinib on Ventricular Arrhythmia in Spontaneously Hypertensive Rats. Beibei Du, Praloy Chakraborty, Mohammed Ali Azam, Stéphane Massé, Patrick F.H. Lai, Ahmed Niri BEng, Daoyuan Si, Paaladinesh Thavendiranathan, Husam Abdel-Qadir, Filio Billia, Kumaraswamy Nanthakumar JACC: CardioOncology Volume 2, Issue 4, November 2020, Pages 614-629 | Isolated heart (rat) | VSD RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA |
| Reverse electromechanical modelling of diastolic dysfunction in spontaneous hypertensive rat after sacubitril/valsartan therapy. Yen]Ling Sung, Ting]Tse Lin, Jhen]Yang Syu, Hung]Jui Hsu, Kai]Yuan Lin, Yen]Bin Liu, Shien]Fong Lin ESC Heart Failure 2020; 7: 4040?4050 | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix. Jiyoung Lee, Akito Sutani, Rin Kaneko, Jun Takeuchi, Tetsuo Sasano, Takashi Kohda, Kensuke Ihara, Kentaro Takahashi, Masahiro Yamazoe, Tomohiro Morio , Tetsushi Furukawa, Fumitoshi Ishino Nat Commun. 2020 Sep 3;11(1):4283. | Organoid | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| The sodium channel NaV1.5 impacts on early murine embryonic cardiac development, structure and function in a non]electrogenic manner. Gerard A. Marchal, Arie O. Verkerk, Rajiv A. Mohan, Rianne Wolswinkel, Bastiaan J. D. Boukens, and Carol Ann Remme Acta Physiol (Oxf). 2020 Oct; 230(2): e13493. | Isolated heart (mouse embryo) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Sacubitril/Valsartan Therapy Ameliorates Ventricular Tachyarrhythmia Inducibility in a Rabbit Myocardial Infarction Model. Po-Cheng Chang, Hung-Ta Wo, Hui-Ling Lee, Shien-Fong Lin, Yen Chu, Ming-Shien Wen, Chung-Chuan Chou J Card Fail. 2020 Jun;26(6):527-537. | Isolated heart (rabbit) | VSD RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Single Bolus Rosuvastatin Accelerates Calcium Uptake and Attenuates Conduction Inhomogeneity in Failing Rabbit Hearts With Regional Ischemia-Reperfusion Injury. Chung-Chuan Chou, Hui-Ling Lee, Yu-Chang Huang, Hung-Ta Wo, Ming-Shien Wen, Yen Chu, Po-Cheng Chang J Cardiovasc Pharmacol. 2020 Jan;75(1):64-74. | Isolated heart (rabbit) | VSD RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity. Matthias Baudot, Eleonora Torre, Isabelle Bidaud, Julien Louradour, Angelo G. Torrente, Lucile Fossier, Leïla Talssi, Joël Nargeot, Stéphanie Barrère-Lemaire, Pietro Mesirca, and Matteo E. Mangoni Sci Rep. 2020; 10: 18906. | SAN/atria preparation (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Mechanisms of ranolazine pretreatment in preventing ventricular tachyarrhythmias in diabetic db/db mice with acute regional ischemia-reperfusion injury. Chung-Chuan Chou, Hui-Ling Lee, Gwo-Jyh Chang, Hung-Ta Wo, Tzung-Hai Yen, Ming-Shien Wen, Yen Chu, Hao-Tien Liu, Po-Cheng Chang Sci Rep. 2020 Nov 18;10(1):20032. | Isolated heart (mouse) | VSD RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices. Sharon A George, Jaclyn A Brennan, Igor R Efimov J Vis Exp. 2020 Jun 16;(160). doi: 10.3791/60781. | Tissue slice (human) | VSD RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Stretchable Conductive Fabric for Cardiac Electrophysiology Applications. Angel Moreno, Richard D. Walton, and Jason D. Bayer ACS Appl. Bio Mater. 2020, 3, 5, 3114?3122 | Isolated heart (rig) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Apelin increases atrial conduction velocity, refractoriness, and prevents inducibility of atrial fibrillation. Young M Kim, Robert Lakin, Hao Zhang, Jack Liu, Ayaaz Sachedina, Maneesh Singh, Emily Wilson, Marco Perez, Subodh Verma, Thomas Quertermous, Jeffrey Olgin, Peter H Backx, Euan A Ashley JCI Insight. 2020 Sep 3;5(17):e126525. | Isolated atria (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Mechanical stimulation of endocardial Purkinje fibres can trigger ventricular arrhythmias. Ed White, Richard Walton, Sarbjot Kaur, Amelia Power, Michel Haïssaguerre, Olivier Bernus, Marie-Louise Ward bioRxiv 2020.08.10.234195 | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Attenuating loss of cardiac conduction during no-flow ischemia through changes in perfusate sodium and calcium. Gregory S Hoeker, Carissa C James, Allison N Tegge, Robert G Gourdie, James W Smyth, Steven Poelzing Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H396-H409. | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Wenli Dai, Rangarajan D. Nadadur, Jaclyn A. Brennan, Heather L. Smith, Kaitlyn M. Shen, Margaret Gadek, Brigitte Laforest, Mingyi Wang, Joanna Gemel, Ye Li, Jing Zhang, Bruce D. Ziman, Jiajie Yan, Xun Ai, Eric C. Beyer, Edward G. Lakata, Narayanan Kasthuri, Igor R. Efimov, Michael T. Broman, Ivan P. Moskowitz, Le Shen, Christopher R. Weber Circulation Research. 2020;127:e28?e43 | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Effects of high-frequency biphasic shocks on ventricular vulnerability and defibrillation outcomes through synchronized virtual electrode responses. Yu-An Chiou, Li-Kuan Cheng, Shien-Fong Lin PLoS One. 2020; 15(5): e0232529. | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Connexin43 expression in bone marrow derived cells contributes to the electrophysiological properties of cardiac scar tissue. Carolina Vasquez, Valeria Mezzano, Newman Kessler, Freja Swardh, Desiree Ernestad, Vanessa M. Mahoney, John Hanna & Gregory E. Morley Scientific Reports volume 10, Article number: 2617 (2020) | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Vascular endothelial growth factor promotes atrial arrhythmias by inducing acute intercalated disk remodeling. Louisa Mezache, Heather L. Struckman, Amara Greer-Short, Stephen Baine, Sándor Györke, Przemysław B. Radwański, Thomas J. Hund and Rengasayee Veeraraghavan Sci Rep. 2020; 10: 20463. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Adrenergic supersensitivity and impaired neural control of cardiac electrophysiology following regional cardiac sympathetic nerve loss. Srinivas Tapa, Lianguo Wang, Samantha D. Francis Stuart, Zhen Wang, Yanyan Jiang, Beth A. Habecker & Crystal M. Ripplinger Scientific Reports volume 10, Article number: 18801 (2020) | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Aging Disrupts Normal Time-of-Day Variation in Cardiac Electrophysiology. Zhen Wang, Srinivas Tapa, Samantha D Francis Stuart, Lianguo Wang, Julie Bossuyt, Brian P Delisle, Crystal M Ripplinger Circ Arrhythm Electrophysiol. 2020 Sep;13(9):e008093. | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Optical Mapping-Validated Machine Learning Improves Atrial Fibrillation Driver Detection by Multi-Electrode Mapping. Alexander M Zolotarev, Brian J Hansen, Ekaterina A Ivanova, Katelynn M Helfrich, Ning Li, Paul M L Janssen, Peter J Mohler, Nahush A Mokadam, Bryan A Whitson, Maxim V Fedorov, John D Hummel, Dmitry V Dylov, Vadim V Fedorov Circ Arrhythm Electrophysiol. 2020 Oct;13(10):e008249. | Isolated atria (human) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA |
| Cold-inducible RNA-binding protein modulates atrial fibrillation onset by targeting multiple ion channels. Duanyang Xie, Li Geng, Shuo Wang, Ke Xiong, Tingting Zhao, Guanghua Wang, Zhiqiang Feng, Fei Lv, Cheng Wang, Dandan Liang, Dan ShiMD, Xiue MaMD, Yi Liu, Jian Yang, Chao Zhang, Yi-Han Chen Heart Rhythm Volume 17, Issue 6, June 2020, Pages 998-1008 | Isolated heart (rat) | VSD (RH-237) | MiCAM ULTIMA |
| What Is the Optimal Light Source for Optical Mapping Using Voltage- and Calcium-Sensitive Dyes? V Olejnickova, D Sedmera Physiol Res. 2020 Aug 31;69(4):599-607 | Isolated heart (chick embryo) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Cardiac sympathetic nerve transdifferentiation reduces action potential heterogeneity after myocardial infarction. Lianguo Wang, Antoinette Olivas, Samantha D Francis Stuart, Srinivas Tapa, Matthew R Blake, William R Woodward, Beth A Habecker, Crystal M Ripplinger Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H558-H565. | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Evidence of Superior and Inferior Sinoatrial Nodes in the Mammalian Heart. Jaclyn A. Brennan, Qing Chen, Anna Gams, Jhansi Dyavanapalli, David Mendelowitz, Weiqun Peng, Igor R.Efimov JACC Clin Electrophysiol. 2020 Dec;6(14):1827-1840. | Isolated atrium (human) | VSD (Di-4-ANEPPS) | MiCAM05 |
| Sudden Heart Rate Reduction Upon Optogenetic Release of Acetylcholine From Cardiac Parasympathetic Neurons in Perfused Hearts. Angel Moreno, Kendal Endicott, Matthew Skancke, Mary Kate Dwyer, Jaclyn Brennan, Igor R. Efimov, Gregory Trachiotis, David Mendelowitz, and Matthew W. Kay Front Physiol. 2019 Sep 4;10:1105. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Acetylcholine Delays Atrial Activation to Facilitate Atrial Fibrillation. Jason D. Bayer, Bastiaan J. Boukens, Sébastien P. J. Krul, Caroline H. Roney, Antoine H. G. Driessen, Wouter R. Berger, Nicoline W. E. van den Berg, Arie O. Verkerk, Edward J. Vigmond, Ruben Coronel, and Joris R. de Groot Front Physiol. 2019 Sep 4;10:1105. | Atrial appendage preparation (human) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Caveolae]Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis. Yuriy V. Egorov, Di Lang, Leonid Tyan, Daniel Turner, Evi Lim, Zachary D. Piro, Jonathan J. Hernandez, Rylie Lodin, Rose Wang, Eric G. Schmuck, Amish N. Raval, Carter J. Ralphe, Timothy J. Kamp, Leonid V. Rosenshtraukh, and Alexey V. Glukhov Sci Rep. 2019; 9: 7502. | Pulmonary vein preparation (rat) | VSD (RH-237) | MiCAM ULTIMA |
| Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12. Zhenwei Pan, Tomohiko Ai, Po-Cheng Chang, Ying Liu, Jijia Liu, Mitsunori Maruyama, Mohamed Homsi, Michael C. Fishbein, Michael Rubart, Shien-Fong Lin, Deyong Xiao, Hanying Chen, Peng-Sheng Chen, Weinian Shou and Bai-Yan Li Am J Physiol Heart Circ Physiol. 2019 Feb 1; 316(2): H371?H379. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na+ current, contractility, and Ca2+ release in murine hearts. Pavel Zhabyeyev, Brent McLean, Xueyi Chen, Bart Vanhaesebroeck, Gavin Y. Oudit Theranostics. 2019; 9(24): 7222?7238. | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice. Satsuki Sato, Jinya Suzuki, Masamichi Hirose, Mika Yamada, Yasuo Zenimaru, Takahiro Nakaya, Mai Ichikawa, Michiko Imagawa, Sadao Takahashi, Shoichiro Ikuyama, Tadashi Konoshita, Fredric B Kraemer, Tamotsu Ishizuka Am J Physiol Endocrinol Metab. 2019 Dec 1;317(6):E1193-E1204. | Isolated heart (mouse) | VSD (RH-237) | MiCAM02 |
| Short-Long Heart Rate Variation Increases Dispersion of Action Potential Duration in Long QT Type 2 Transgenic Rabbit Model. Tae Yun Kim, Paul Jeng, JungMin Hwang, Zachary Pfeiffer, Divyang Patel, Leroy L Cooper, Konstantinos Kossidas, Jason Centracchio, Xuwen Peng, Gideon Koren, Zhilin Qu, Bum-Rak Choi Sci Rep. 2019 Oct 16;9(1):14849. | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts. Shanna Hamilton, Iuliia Polina, Radmila Terentyeva, Peter Bronk, Tae Yun Kim, Karim Roder, Richard T Clements, Gideon Koren, Bum-Rak Choi, Dmitry Terentyev J Physiol. 2020 Jul;598(14):2847-2873. | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Joshua W Vincentz, Beth A Firulli, Kevin P Toolan, Dan E Arking, Nona Sotoodehnia, Juyi Wan, Peng-Sheng Chen, Corrie de Gier-de Vries, Vincent M Christoffels, Michael Rubart-von der Lohe, Anthony B Firulli Circ Res. 2019 Aug 30;125(6):575-589. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Absence of natriuretic peptide clearance receptor attenuates TGF-β1-induced selective atrial fibrosis and atrial fibrillation. Dolkun Rahmutula, Hao Zhang, Emily E Wilson, Jeffrey E Olgin Cardiovasc Res. 2019 Feb 1;115(2):357-372. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling. Brian Martin, Beth Gabris, Amr F. Barakat, Brian L. Henry, Marianna Giannini, Rajiv P. Reddy, Xuewen Wang, Guillermo Romero & Guy Salama Scientific Reports volume 9, Article number: 18545 (2019) | Isolated heart (rat) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Heterogeneity of the action potential duration is required for sustained atrial fibrillation. Uma Mahesh R. Avula, Jeffrey Abrams, Alexander Katchman, Sergey Zakharov, Sergey Mironov, Joseph Bayne, Daniel Roybal, Anirudh Gorti, Lin Yang, Vivek Iyer, Marc Waase, Deepak Saluja, Edward J. Ciaccio, Hasan Garan, Andrew R. Marks, Steven O. Marx, and Elaine Y. Wan JCI Insight. 2019 Apr 25;5(11):e128765. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice. Simona Casini, Maxime Albesa, Zizun Wang, Vincent Portero, Daniela Ross-Kaschitza, Jean-Sébastien Rougier, Gerard A. Marchal, Wendy K. Chung, Connie R. Bezzina, Hugues Abriel, and Carol Ann Remme Int J Mol Sci. 2019 Oct; 20(20): 5033. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Wide-area low-energy surface stimulation of large mammalian ventricular tissue. Angel Moreno, Richard D Walton, Marion Constantin, Olivier Bernus, Edward J Vigmond, Jason D Bayer Front Physiol. 2019 Feb 26;10:146. | Ventricular wedge preparation (pig) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Optical Imaging of Ventricular Action Potentials in a Torso Tank: A New Platform for Non-Invasive Electrocardiographic Imaging Validation. Laura R Bear, Richard D Walton, Emma Abell, Yves Coudière, Michel Haissaguerre, Olivier Bernus, Rémi Dubois Front Physiol. 2019 Feb 26;10:146. | Isolated heart (pig) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA |
| Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. Philipp Gutruf, Rose T Yin, K Benjamin Lee, Jokubas Ausra, Jaclyn A Brennan, Yun Qiao, Zhaoqian Xie, Roberto Peralta, Olivia Talarico, Alejandro Murillo, Sheena W Chen, John P Leshock, Chad R Haney, Emily A Waters, Changxing Zhang, Haiwen Luan, Yonggang Huang, Gregory Trachiotis, Igor R Efimov, John A Rogers Nat Commun. 2019 Dec 17;10(1):5742. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Simplified platform for mosaic in vivo analysis of cellular maturation in the developing heart. Julie Goudy, Trevor Henley, Hernán G. Méndez and Michael Bressan Scientific Reports volume 9, Article number: 10716 (2019) | Isolated heart (chick embryo) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Inhibition of soluble TNFα prevents adverse atrial remodeling and atrial arrhythmia susceptibility induced in mice by endurance exercise. Robert Lakin, Nazari Polidovitch, Sibao Yang, Camilo Guzman, Xiaodong Gao, Marianne Wauchop, Jacob Burns, Farzad Izaddoustdar, Peter H Backx J Mol Cell Cardiol. 2019 Apr;129:165-173. | Isolated atria (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. Lianguo Wang, Stefano Morotti, Srinivas Tapa, Samantha D Francis Stuart, Yanyan Jiang, Zhen Wang, Rachel C Myles, Kieran E Brack, G André Ng, Donald M Bers, Eleonora Grandi, Crystal M Ripplinger J Physiol. 2019 Aug;597(15):3867-3883. | Isolated heart (rabbit) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo. Tanner O Monroe, Matthew C Hill, Yuka Morikawa, John P Leach, Todd Heallen, Shuyi Cao, Peter H L Krijger, Wouter de Laat, Xander H T Wehrens, George G Rodney, James F Martin Dev Cell. 2019 Mar 25;48(6):765-779.e7. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Exposure to Secondhand Smoke and Arrhythmogenic Cardiac Alternans in a Mouse Model. Zhen Wang, Lianguo Wang, Srinivas Tapa, Kent E. Pinkerton, Chao-Yin Chen and Crystal M. Ripplinger Environmental Health Perspectives. 126(12) December 2018 | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Ventricular Endocardial Tissue Geometry Affects Stimulus Threshold and Effective Refractory Period. Adam Connolly, Allen Kelly, Fernando O. Campos, Rachel Myles, Godfrey Smith and Martin J. Bishop Biophys J. 2018 Dec 18;115(12):2486-2498. | Ventricular wedge preparation (rabbit) | VSD (RH-237) | MiCAM ULTIMA |
| Critical Volume of Human Myocardium Necessary to Maintain Ventricular Fibrillation. Kedar K. Aras, Ndeye Rokhaya Faye, Brianna Cathey and Igor R. Efimov Circ Arrhythm Electrophysiol. 2018 Nov;11(11):e006692. | Ventricular wedge preparation (human) | VSD (Di-4-ANBDQBS) | MiCAM05 (quad camera) |
| Arrhythmogenic Remodeling of the Left Ventricle in a Porcine Model of Repaired Tetralogy of Fallot. Virginie Dubes, David Benoist, François Roubertie, Stephen H. Gilbert, Marion Constantin, Sabine Charron, Delphine Elbes, Delphine Vieillot, Bruno Quesson, Hubert Cochet, Michel Haïssaguerre, Caroline Rooryck, Pierre Bordachar, Jean-Benoit Thambo, and Olivier Bernus Circ Arrhythm Electrophysiol. 2018;11:e006059. | Ventricular wedge preparation (pig) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling. Yong Zhang, Lihua Sun, Lina Xuan, Zhenwei Pan, Xueling Hu, Hongyu Liu, Yunlong Bai, Lei Jiao, Zhange Li, Lina Cui, Xiaoxue Wang, Siqi Wang, Tingting Yu, Bingbing Feng, Ying Guo, Zonghong Liu, Weixin Meng, Hequn Ren, Jiyuan Zhu, Xuyun Zhao, Chao Yang, Ying Zhang, Chaoqian Xu, Zhiguo Wang, Yanjie Lu, Hongli Shan, and Baofeng Yang Nat Commun. 2018 Oct 9;9(1):4176. | Isolated heart (mouse) | VSD (RH-237) | MiCAM05 |
| CRISPR]Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias. Paul D. Pang, Katherina M. Alsina, Shuyi Cao, Amrita B. Koushik, Xander H.T. Wehrens and Thomas A. Cooper J Am Heart Assoc. 2018;7:e010393. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure. Anyu Zhou, An Xie, Tae Yun Kim, Hong Liu, Guangbin Shi, Gyeoung-Jin Kang, Ning Jiang, Man Liu, Euy-Myoung Jeong, Bum-Rak Choi, and Samuel C. Dudley Jr. Heart Rhythm. 2018 Jul;15(7):1072-1080. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Role of the Purkinje-Muscle Junction on the Ventricular Repolarization Heterogeneity in the Healthy and Ischemic Ovine Ventricular Myocardium. Marine E. Martinez, Richard D. Walton, Jason D. Bayer, Michel Haïssaguerre, Edward J. Vigmond, Mélèze Hocini and Olivier Bernus Front Physiol. 2018 Jun 14;9:718. | Ventricular wedge preparation (sheep) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA |
| Small-conductance Ca2+-activated K+ channel activation deteriorates hypoxic ventricular arrhythmias via CaMKII in cardiac hypertrophy. Taro Tenma, Hirofumi Mitsuyama, Masaya Watanabe, Naoya Kakutani, Yutaro Otsuka, Kazuya Mizukami, Rui Kamada, Masayuki Takahashi, Shingo Takada, Hisataka Sabe, Hiroyuki Tsutsui, and Hisashi Yokoshiki Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H262-H272. | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM02 |
| Absence of NPR-C Attenuates TGF-s1 Induced Selective Atrial Fibrosis and Atrial Fibrillation. Dolkun Rahmutula, Hao Zhang, Emily E Wilson and Jeffrey E Olgin Cardiovasc Res. 2018 Sep 18. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Essential Role of RyR2 Phosphorylation in the Effect of Azumolene on Ventricular Arrhythmia Vulnerability in a Rabbit Heart Model. Daoyuan Si, Mohammed Ali Azam, Patrick F.H. Lai, Nima Zamiri, Galina Kichigina, John Asta, Stéphane Massé, Mahmoud M. Bokhari, Andreu Porta]Sánchez, Christopher Labos, Huan Sun, Ping Yang and Kaumaraswamy Nanthakumar J Cardiovasc Electrophysiol. 2018 Sep 11. | Isolated heart (rabbit) | CaSD (Rhod-2 AM) | MiCAM ULTIMA |
| Apoptosis and epicardial contributions act as complementary factors in remodeling of the atrioventricular canal myocardium and atrioventricular conduction patterns in the embryonic chick heart. Rebecca Vicente Steijn, David Sedmera, Nico A. Blom, Monique Jongbloed, Alena Kvasilova, and Ondrej Nanka Dev Dyn. 2018 Sep;247(9):1033-1042. | Isolated heart (chick embryo) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Effects of long-term exercise on arrhythmogenesis in aged hypertensive rats. Yen-Ling Sung, Chih-En Wu, Jhen-Yang Syu,Terry B.J.Kuo, Jai-YiLi, Chieh-Wen Chen, Ching-Hui Weng, Wei-Hsuan Hsu, Shih-Ann Chen, Yu-Feng Hu and Shien-Fong Lin Comput Biol Med. 2018 Aug 16. pii: S0010-4825(18)30236-1. | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Compartmentalized Structure of the Moderator Band Provides a Unique Substrate for Macroreentrant Ventricular Tachycardia. Richard D. Walton, Ali Pashaei, Marine E. Martinez, Marion Constantin, Josselin Duchateau, Laura Bear, Caroline Cros, Caroline Pascarel-Auclerc, Yunbo Guo, David Benoist, Virginie Dubes, Ndeye Rokhaya Faye, Sebastien Chaigne, Sebastien Dupuis, Dominique Détaille, Line Pourtau, Philippe Pasdois, Fabien Brette, Julien Rogier, Louis Labrousse, Mélèze Hocini, Edward J. Vigmond, Michel Haïssaguerre and Olivier Bernus Circulation: Arrhythmia and Electrophysiology. 2018;11:e005913 | Ventricular wedge preparation (sheep, human) | VSD (Di]4]ANBDQBS) | MiCAM ULTIMA |
| CaMKII-dependent late Na+ current increases electrical dispersion and arrhythmia in ischemia-reperfusion. Taylor Howard, Amara Greer-Short, Tony Satroplus, Nehal Patel, Drew Nassal, Peter J. Mohler, and Thomas J. Hund Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H794-H801. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM05 |
| LncRNA ZFAS1 as a SERCA2a Inhibitor to Cause Intracellular Ca2+ Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction. Ying Zhang, Lei Jiao, Lihua Sun, Yanru Li, Yuqiu Gao, Chaoqian Xu, Yingchun Shao, Mengmeng Li, Chunyan Li, Yanjie Lu, Zhenwei Pan, Lina Xuan, Yiyuan Zhang, Qingqi Li, Rui Yang, Yuting Zhuang, Yong Zhang and Baofeng Yang Circ Res. 2018 May 11; 122(10): 1354?1368. | Isolated heart (mouse) | CaSD (Rhod-2 AM) | MiCAM05 |
| Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation. Samantha D. Francis Stuart, Lianguo Wang, William R. Woodard, G. Andre Ng, Beth A. Habecker and Crystal M. Ripplinger J Physiol. 2018 Jun 25. | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility. Diana C. Parrish, Samantha D. Francis Stuart, Antoinette Olivas, Lianguo Wang, Anders Nykjaer, Crystal M. Ripplinger, and Beth A. Habecker Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H415-H423. | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure. Anyu Zhou, An Xie, Tae Yun Kim, Hong Liu, Guangbin Shi, Gyeoung-Jin Kang, Ning Jiang, Man Liu, Euy-Myoung Jeong, Bum-Rak Choi, Samuel C. Dudley Jr. Heart Rhythm. 2018 Feb 16. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy. Qiongling Wang, Ann P. Quick, Shuyi Cao, Julia Reynolds, David Y. Chiang, David Beavers, Na Li, Guoliang Wang, George G. Rodney, Mark E. Anderson, Xander H.T. Wehrens. Circ Arrhythm Electrophysiol. 2018 Apr;11(4):e005682. | Isolated heart (mouse) | VSD (RH-237) | MiCAM ULTIMA |
| Ondansetron Blocks Wildtype and p.F503L Variant Small Conductance Calcium Activated Potassium Channels. Jum-Suk Ko, Shuai Guo, Jonathan Hassel, Patricia Celestino-Soper, Ty C Lynnes, James E Tisdale, James J Zheng, Stanley E Taylor, Tatiana Foroud, Michael D Murray, Richard J Kovacs, Xiaochun Li, Shien-Fong Lin, Zhenhui Chen, Matteo Vatta, Peng-Sheng Chen, and Michael Rubart Am J Physiol Heart Circ Physiol. 2018 Apr 20. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling. Wilhelm Roell, Alexandra M. Klein, Martin Breitbach, Torsten S. Becker, Ashish Parikh, Jane Lee, Katrin Zimmermann, Shaun Reining, Beth Gabris, Annika Ottersbach, Robert Doran, Britta Engelbrecht, Miriam Schiffer, Kenichi Kimura, Patricia Freitag, Esther Carls, Caroline Geisen, Georg D. Duerr, Philipp Sasse, Armin Welz, Alexander Pfeifer, Guy Salama, Michael Kotlikoff & Bernd K. Fleischmann Sci Rep. 2018 May 8;8(1):7145. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Electrophysiologic effects of the IK1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts. Gregory S. Hoeker, Mark A. Skarsfeldt, Thomas Jespersen, and Steven Poelzing Physiol Rep. 2017 Jan;5(1). pii: e13120. doi: 10.14814/phy2.13120. Epub 2017 Jan 13. | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure. Ning Li, Brian J. Hansen, Thomas A. Csepe, Jichao Zhao, Anthony J. Ignozzi, Lidiya V. Sul, Stanislav O. Zakharkin, Anuradha Kalyanasundaram, Jonathan P. Davis, Brandon J. Biesiadecki, Ahmet Kilic, Paul M. L. Janssen, Peter J. Mohler, Raul Weiss, John D. Hummel and Vadim V. Fedorov Sci Transl Med. 2017 Jul 26;9(400). | SAN preparation (human) | VSD (Di]4]ANBDQBS) | MiCAM ULTIMA (dual or quad camera) |
| Three-dimensional Integrated Functional, Structural, and Computational Mapping to Define the Structural "Fingerprints" of Heart-Specific Atrial Fibrillation Drivers in Human Heart Ex Vivo. Jichao Zhao, Brian J. Hansen, Yufeng Wang, Thomas A. Csepe, Lidiya V. Sul, Alan Tang, Yiming Yuan, Ning Li, Anna Bratasz, Kimerly A. Powell, Ahmet Kilic, Peter J. Mohler, Paul M. L. Janssen, Raul Weiss, Orlando P. Simonetti, John D. Hummel, and Vadim V. Fedorov J Am Heart Assoc. 2017 Aug 22;6(8). | Atrial tissue (human) | VSD (Di]4]ANBDQBS) | MiCAM ULTIMA |
| Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Padmini Sirish, Ning Li, Valeriy Timofeyev, Xiao-Dong Zhang, Lianguo Wang, Jun Yang, Kin Sing S. Lee, Ahmed Bettaieb, Sin Mei Ma, Jeong Han Lee, Demetria Su, Victor C. Lau, Richard E. Myers, Deborah K. Lieu, Javier E. López, J. Nilas Young, Ebenezer N. Yamoah, Fawaz Haj, Crystal M. Ripplinger, Bruce D. Hammock, and Nipavan Chiamvimonvat Circ Arrhythm Electrophysiol. 2016 May; 9(5) | Isolated heart (mouse) | VSD (RH-237) | MiCAM ULTIMA |
| Anti-arrhythmic effects of interleukin-1 inhibition following myocardial infarction. Nicole M. De Jesus, Lianguo Wang, Johnny Lai, Robert R. Rigor, Samantha D. Francis Stuart, Donald M. Bers, Merry L. Lindsey, and Crystal M. Ripplinger Heart Rhythm. 2017 May; 14(5): 727?736. | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| β-Adrenergic Inhibition Prevents Action Potential and Calcium Handling Changes during Regional Myocardial Ischemia. Shannon R. Murphy, Lianguo Wang, Zhen Wang, Philip Domondon, Di Lang,1 Beth A. Habecker, Rachel C. Myles, and Crystal M. Ripplinger Front Physiol. 2017 Aug 28;8:630. | Isolated heart (rabbit) | VSD (RH-237) CaSD (Fluo-5N AM) | MiCAM ULTIMA (dual camera) |
| β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle. C. Kang, A. Badiceanu, J. A. Brennan, C. Gloschat, Y. Qiao, N. A. Trayanova, and I. R. Efimov Sci Rep. 2017 Nov 21;7(1):15922. | Ventricular wedge preparation (human) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Human Organotypic Cultured Cardiac Slices: New Platform For High Throughput Preclinical Human Trials. C. Kang, Y. Qiao, G. Li, K. Baechle, P. Camelliti, S. Rentschler, and I. R. Efimov Sci Rep. 2016; 6: 28798. | Ventricular slice (human) | VSD (Di-4-ANEPPS and RH-237) CaSD (Rhod-2) | MiCAM ULTIMA |
| Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart. Vanessa M. Mahoney, Valeria Mezzano, Gary R. Mirams, Karen Maass, Zhen Li, Marina Cerrone, Carolina Vasquez, Aneesh Bapat, Mario Delmar, and Gregory E. Morley Sci Rep. 2016 May 31;6:26744. doi: 10.1038/srep26744. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Optogenetic termination of ventricular arrhythmias in the whole heart: towards biological cardiac rhythm management. Emile C.A. Nyns, Annemarie Kip, Cindy I. Bart, Jaap J. Plomp; Katja Zeppenfeld, Martin J. Schalij, Antoine A.F. de Vries, Daniël A. Pijnappels Eur Heart J. 2016 Dec 23. pii: ehw574. doi: 10.1093/eurheartj/ehw574. [Epub ahead of print] | Isolated heart (rat) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA |
| Resolving Myocardial Activation With Novel Omnipolar Electrograms. Stéphane Massé, Karl Magtibay, Nicholas Jackson, John Asta, Marjan Kusha, Boyang Zhang, Ram Balachandran, Milica Radisic, D. Curtis Deno, and Kumaraswamy Nanthakumar Circ Arrhythm Electrophysiol. 2016 Jul;9(7):e004107. doi: 10.1161/CIRCEP.116.004107. | Isolated heart (rabbit) | VSD (Di-4-ANBDQPQ) | MiCAM ULTIMA |
| Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. Elaine Wan, Jeffrey Abrams, Richard L. Weinberg, Alexander N. Katchman, Joseph Bayne, Sergey I. Zakharov, Lin Yang, John P. Morrow, Hasan Garan, and Steven O. Marx J Clin Invest. 2016 Jan;126(1):112-22. doi: 10.1172/JCI84669. Epub 2015 Nov 23. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. Elaine Wan, Jeffrey Abrams, Richard L. Weinberg, Alexander N. Katchman, Joseph Bayne, Sergey I. Zakharov, Lin Yang, John P. Morrow, Hasan Garan, and Steven O. Marx J Clin Invest. 2016 Jan;126(1):112-22. doi: 10.1172/JCI84669. Epub 2015 Nov 23. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Extracellular sodium dependence of the conduction velocity-calcium relationship: evidence of ephaptic self-attenuation. Sharon A. George, Mohammad Bonakdar, Michael Zeitz, Rafael V. Davalos, James W. Smyth, Steven Poelzing Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1129-39. doi: 10.1152/ajpheart.00857.2015. Epub 2016 Mar 4. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Heart Rate and Extracellular Sodium and Potassium Modulation of Gap Junction Mediated Conduction in Guinea Pigs. Michael Entz, II, Sharon A. George, Michael J. Zeitz, Tristan Raisch, James W. Smyth, and Steven Poelzing Front Physiol. 2016 Feb 2;7:16. doi: 10.3389/fphys.2016.00016. eCollection 2016. | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart. Ning Li, Thomas A. Csepe, Brian J. Hansen, Lidiya V. Sul, Anuradha Kalyanasundaram, Stanislav O. Zakharkin, Jichao Zhao, Avirup Guha, David R. Van Wagoner, Ahmet Kilic, Peter J. Mohler, Paul M. L. Janssen, Brandon J. Biesiadecki, John D. Hummel, Raul Weiss and Vadim V. Fedorov Circulation. 2016 Aug 9;134(6):486-98. doi: 10.1161/CIRCULATIONAHA.115.021165. Epub 2016 Jul 26. | Atria tissue (human) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA (dual or quad camera) |
| Spontaneous initiation of premature ventricular complexes and arrhythmias in type 2 long QT syndrome. Xiaodong Huang, Tae Yun Kim, Gideon Koren, Bum-Rak Choi and Zhilin Qu Am J Physiol Heart Circ Physiol. 2016 Oct 7:ajpheart.00500.2016. doi: 10.1152/ajpheart.00500.2016. [Epub ahead of print] | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure. David S. Park, Akshay Shekhar, Christopher Marra, Xianming Lin, Carolina Vasquez, Sergio Solinas, Kevin Kelley, Gregory Morley, Mitchell Goldfarb, and Glenn I. Fishman Nat Commun. 2016 Oct 4;7:12966. doi: 10.1038/ncomms12966. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Potassium channels in the Cx43 gap junction perinexus modulate ephaptic coupling: an experimental and modeling study. Rengasayee Veeraraghavan, Joyce Lin, James P. Keener, Robert Gourdie and Steven Poelzing Pflugers Arch. 2016 Oct;468(10):1651-61. doi: 10.1007/s00424-016-1861-2. Epub 2016 Aug 11. | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM02 |
| Acute temperature effects on function of the chick embryonic heart. Vostarek F, Svatunkova J, Sedmera D Acta Physiol (Oxf). 2016 Aug;217(4):276-86. doi: 10.1111/apha.12691. Epub 2016 May 12. | Isolated heart (chick embryo) | VSD (Di-4-ANEPPS) CaSD (Rhod-2) | MiCAM ULTIMA |
| Increased susceptibility of spontaneously hypertensive rats to ventricular tachyarrhythmias in early hypertension. Thao P. Nguyen, Ali A. Sovari, Arash Pezhouman, Shankar Iyer, Hong Cao, Christopher Y. Ko, Aneesh Bapat, Nooshin Vahdani, Mostafa Ghanim, Michael C. Fishbein, and Hrayr S. Karagueuzian J Physiol. 2016 Mar 15;594(6):1689-707. doi: 10.1113/JP271318. Epub 2016 Jan 18. | Isolated heart (rat) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Molecular Basis of Hypokalemia-Induced Ventricular Fibrillation. Arash Pezhouman, Neha Singh, Zhen Song, Michael Nivala, Anahita Eskandari, Hong Cao, Aneesh Bapat, Christopher Y. Ko, Thao Nguyen, Zhilin Qu, Hrayr S. Karagueuzian and James N. Weiss Circulation. 2015 Oct 20;132(16):1528-37. doi: 10.1161/CIRCULATIONAHA.115.016217. Epub 2015 Aug 12. | Isolated heart (rabbit) | VSD (RH-237) | MiCAM ULTIMA |
| Myocardial Infarction Causes Transient Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via gp130. Antoinette Olivas, Ryan T. Gardner, Lianguo Wang, Crystal M. Ripplinger, William R. Woodward and Beth A. Habecker J Neurosci. 2016 Jan 13;36(2):479-88. doi: 10.1523/JNEUROSCI.3556-15.2016. | Isolated heart (rabbit) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Deletion of the Serotonin Receptor Type 3A in Mice Leads to Sudden Cardiac Death During Pregnancy. Hyewon Park, Chang-Myung Oh, Junbeom Park, Hyelim Park, Shanyu Cui, Hyung Suk Kim, Jun Namkung, Sang-kyu Park, Hui-Nam Pak, Moon-Hyoung Lee, Hail Kim, and Boyoung Joung Circ J. 2015;79(8):1807-15. doi: 10.1253/circj.CJ-14-1074. Epub 2015 May 15. | Isolated heart (mouse) | VSD (RH-237) | MiCAM ULTIMA |
| Extracellular sodium and potassium levels modulate cardiac conduction in mice heterozygous null for the Connexin43 gene. Sharon A George, Katherine J. Sciuto, Joyce Lin, Mohamed E Salama, James P Keener, Robert G Gourdie, and Steven Poelzing Pflugers Arch. 2015 Nov;467(11):2287-97. doi: 10.1007/s00424-015-1698-0. Epub 2015 Mar 14. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways. Thomas A. Csepe, Jichao Zhao, Brian J. Hansen, Ning Li, Lidiya V. Sul, Praise Lim, Yufeng Wang, Orlando P. Simonetti, Ahmet Kilic, Peter J. Mohler, Paul M.L. Janssen, Vadim V. Fedorov Prog Biophys Mol Biol. 2015 Dec 30. pii: S0079-6107(15)00260-6. doi: 10.1016/j.pbiomolbio.2015.12.011. [Epub ahead of print] | SAN tissue | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA |
| Integration of High-Resolution Optical Mapping and 3-Dimensional Micro-Computed Tomographic Imaging to Resolve the Structural Basis of Atrial Conduction in the Human Heart. Jichao Zhao, Brian J. Hansen, Thomas A. Csepe, Praise Lim, Yufeng Wang, Michelle Williams, Peter J. Mohler, Paul M.L. Janssen, Raul Weiss, John D. Hummel, and Vadim V. Fedorov Circ Arrhythm Electrophysiol. 2015 Dec;8(6):1514-7. doi: 10.1161/CIRCEP.115.003064. | Isolated atria (human) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA |
| Repolarization Alternans and Ventricular Arrhythmia in a Repaired Tetralogy of Fallot Animal Model. Shuenn]Nan Chiu, Chia]Ti Tsai, Lian]Yu Lin, Shu]Chien Huang, Yih]Sharng Chen, Jou]Kou Wang, Mei]Hwan Wu, Ling]Ping Lai and Jiunn]Lee Lin J Am Heart Assoc. 2015 Dec 11;4(12). pii: e002173. doi: 10.1161/JAHA.115.002173. | Ventricle wedge preparation (dog) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA |
| Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. Elaine Wan, Jeffrey Abrams, Richard L. Weinberg, Alexander N. Katchman, Joseph Bayne, Sergey I. Zakharov, Lin Yang, John P. Morrow, Hasan Garan and Steven O. Marx J Clin Invest. 2016 Jan 4;126(1):112-22. doi: 10.1172/JCI84669. Epub 2015 Nov 23. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart. Di Lang, Katherine Holzem, Chaoyi Kang, Mengqian Xiao, Hye Jin Hwang, Gregory A. Ewald, Kathryn A. Yamada, and Igor R. Efimov Circ Arrhythm Electrophysiol. 2015 Apr;8(2):409-19. doi: 10.1161/CIRCEP.114.002065. Epub 2015 Feb 11. | Ventricle wedge preparation (human) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node. Hengtao Zhang, Albert Y. Sun, Jong J. Kim, Victoria Graham, Elizabeth A. Finch, Igor Nepliouev, Guiling Zhao, Tianyu Li, W. J. Lederer, Jonathan A. Stiber, Geoffrey S. Pitt, Nenad Bursac and Paul B. Rosenberg Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):E5618-27. doi: 10.1073/pnas.1503847112. Epub 2015 Sep 30. | SAN tissue | CaSD (Rhod-2 AM) | MiCAM ULTIMA |
| Diet-induced obesity promotes altered remodeling and exacerbated cardiac hypertrophy following pressure overload. Katherine M. Holzem, Joseph T. Marmerstein, Eli J. Madden and Igor R. Efimov Physiol Rep. 2015 Aug;3(8). pii: e12489. doi: 10.14814/phy2.12489. | Isolated heart (mouse) | VSD (RH-237) | MiCAM ULTIMA |
| Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts. Brian J. Hansen, Jichao Zhao, Thomas A. Csepe, Brandon T. Moore, Ning Li, Laura A. Jayne, Anuradha Kalyanasundaram, Praise Lim, Anna Bratasz, Kimerly A. Powell, Orlando P. Simonetti, Robert S.D. Higgins, Ahmet Kilic, Peter J. Mohler, Paul M.L. Janssen, Raul Weiss, John D. Hummel and Vadim V. Fedorov Eur Heart J. 2015 Jun 8. pii: ehv233. [Epub ahead of print]. | Isolated heart (human) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA (dual camera) |
| Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice. Angelo G. Torrente, Rui Zhang, Audrey Zaini, Jorge F. Giani, Jeanney Kang, Scott T. Lamp, Kenneth D. Philipson and Joshua I. Goldhaber Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9769-74. doi: 10.1073/pnas.1505670112. Epub 2015 Jul 20. | SAN/atria tissue | VSD (RH-237) | MiCAM ULTIMA |
| Engineered heart slices for electrophysiological and contractile studies. Adriana Blazeski, Geran M. Kostecki and Leslie Tung Biomaterials. 2015 Jul;55:119-28. doi: 10.1016/j.biomaterials.2015.03.026. Epub 2015 Apr 17. | Heart slice | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model. Milan Gautam, Daiki Fujita, Kazuhiro Kimura, Hinako Ichikawa, Atsushi Izawa, Masamichi Hirose, Toshihide Kashihara, Mitsuhiko Yamada, Masafumi Takahashi, Uichi Ikeda and Yuji Shiba J Mol Cell Cardiol. 2015 Apr;81:139-49. doi: 10.1016/j.yjmcc.2015.02.012. Epub 2015 Feb 24. | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM02 |
| Quantification of the Transmural Dynamics of Atrial Fibrillation by Simultaneous Endocardial and Epicardial Optical Mapping in an Acute Sheep Model. Sarah R. Gutbrod, Richard Walton, Stephen Gilbert, Valentin Meillet, Pierre Jaïs, Mélèze Hocini, Michel Haïssaguerre, Rémi Dubois, Olivier Bernus and Igor Efimov Circ Arrhythm Electrophysiol. 2015 Feb 24. pii: CIRCEP.114.002545. [Epub ahead of print] | Isolated atria (sheep) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA (dual camera) |
| Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias. R. T. Gardner, L. Wang, B. T. Lang, J. M. Cregg, C. L. Dunbar, W. R. Woodward, J. Silver, C. M. Ripplinger and B. A. Habecker Nat Commun. 2015 Feb 2;6:6235. doi: 10.1038/ncomms7235. | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study. Rengasayee Veeraraghavan, Joyce Lin, Gregory S. Hoeker, James P. Keener, Robert G. Gourdie and Steven Poelzing Pflugers Arch. 2015 Jan 13. [Epub ahead of print] | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM02 |
| Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation. Nicole M. De Jesus, Lianguo Wang, Anthony W. Herren, Jingjing Wang, Fatemah Shenasa, Donald M. Bers, Merry L. Lindsey and Crystal M. Ripplinger Heart Rhythm. 2015 Jan;12(1):169-78. doi: 10.1016/j.hrthm.2014.10.007. Epub 2014 Oct 7. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Optical Mapping of Intra-Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Langendorff-perfused Rabbit Heart. Lianguo Wang, Nicole M. De Jesus, and Crystal M. Ripplinger J Vis Exp. 2015 Sep 10;(103) | Isolated heart (rabbit) | VSD (RH-237) CaSD (Fluo-5N AM) | MiCAM ULTIMA (dual camera) |
| Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias. Qing Lou, Andriy E. Belevych, Przemysław B. Radwański, Bin Liu, Anuradha Kalyanasundaram, Bjorn C. Knollmann, Vadim V. Fedorov and Sándor Györke J Physiol. 2014 Nov 10. [Epub ahead of print] | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Pacing-Induced Non-Uniform Ca2+ Dynamics in Rat Atria Revealed by Rapid-Scanning Confocal Microscopy. Yan Jiang, Hideo Tanaka, Taka-aki Matsuyama, Yoshihisa Yamaoka and Tetsuro Takamatsu Acta Histochem Cytochem. May 1, 2014; 47(2): 59-65. Published online Apr 25, 2014. doi: 10.1267/ahc.14014 | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM02 |
| Ca2+/calmodulin-dependent protein kinase II increases the susceptibility to the arrhythmogenic action potential alternans in spontaneously hypertensive rats. Hirofumi Mitsuyama, Hisashi Yokoshiki, Masaya Watanabe, Kazuya Mizukami, Junichi Shimokawa and Hiroyuki Tsutsui Am J Physiol Heart Circ Physiol. 2014 Jul 15;307(2):H199-206. doi: 10.1152/ajpheart.00387.2012. Epub 2014 May 23. | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM02 |
| Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Lianguo Wang, Rachel C. Myles, Nicole M. De Jesus, Alex K.P. Ohlendorf, Donald M. Bers and Crystal M. Ripplinger Circ Res. 2014 Apr 25;114(9):1410-21. doi: 10.1161/CIRCRESAHA.114.302505. Epub 2014 Feb 25. | Isolated heart (rabbit) | VSD (RH-237) CaSD (Fluo-5N AM) | MiCAM ULTIMA (dual camera) |
| Decreased IK1 and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart. Rachel C. Myles, Lianguo Wang, Donald M. Bers and Crystal M. Ripplinger J Physiol. 2014 Sep 5. [Epub ahead of print] | Isolated heart (rabbit) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Mitochondrial depolarization and electrophysiological changes during ischemia in the rabbit and human heart. Matthew S Sulkin, Bastiaan J Boukens, Megan Tetlow, Sarah R Gutbrod, Fu Siong Ng and Igor R. Efimov Am J Physiol Heart Circ Physiol. 2014 Aug 15. pii: ajpheart.00437.2014. [Epub ahead of print] | Isolated heart (mouse) | VSD (RH-237 and TMRM) | MiCAM ULTIMA (dual camera) |
| Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping. Qing Lou, Brian J. Hansen, Olga Fedorenko, Thomas A. Csepe, Anuradha Kalyanasundaram, Ning Li, Lori T. Hage, Alexey V. Glukhov, George E. Billman, Raul Weiss, Peter J. Mohler, Sándor Györke, Brandon J. Biesiadecki, Cynthia A. Carnes, PharmD and Vadim V. Fedorov Circulation. 2014 Jul 22;130(4):315-24. doi: 10.1161/CIRCULATIONAHA.113.007086. Epub 2014 May 16. | Isolated heart (dog) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA (dual camera) |
| 3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium. Lizhi Xu, Sarah R. Gutbrod, Andrew P. Bonifas, Yewang Su, Matthew S. Sulkin, Nanshu Lu, Hyun-Joong Chung, Kyung-In Jang, Zhuangjian Liu, Ming Ying, Chi Lu, R. Chad Webb, Jong-Seon Kim, Jacob I. Laughner, Huanyu Cheng, Yuhao Liu, Abid Ameen, Jae-Woong Jeong, Gwang-Tae Kim, Yonggang Huang, Igor R. Efimov and John A. Rogers Nat Commun. 2014 Feb 25;5:3329. doi: 10.1038/ncomms4329. | Isolated heart (rabbit) | VSD (Di-4-ANEPPS or RH-237) | MiCAM ULTIMA |
| c-Src Kinase Inhibition Reduces Arrhythmia Inducibility and Connexin43 Dysregulation After Myocardial Infarction. Cody A. Rutledge, Fu Siong Ng, Matthew S. Sulkin, Ian D. Greener, Artem M. Sergeyenko, Hong Liu, Joanna Gemel, Eric C. Beyer, Ali A. Sovari, Igor R. Efimov and Samuel C. Dudley J Am Coll Cardiol. 2014 Mar 11;63(9):928-34. doi: 10.1016/j.jacc.2013.10.081. Epub 2014 Jan 8. | Isolated heart (mouse) | VSD (RH-237) | MiCAM ULTIMA |
| Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts. Arash Pezhouman, Sepideh Madahian, Hayk Stepanyan, Hayk Ghukasyan, Zhilin Qu, Luiz Belardinelli and Hrayr S. Karagueuzian Heart Rhythm. 2014 Mar;11(3):492-501. doi: 10.1016/j.hrthm.2013.11.026. Epub 2013 Nov 28. | Isolated heart (rat) | VSD (RH-237) | MiCAM ULTIMA |
| Transmural ultrasound imaging of thermal lesion and action potential changes in perfused canine cardiac wedge preparations by high intensity focused ultrasound ablation. Ziqi Wu, Madhu S. R. Gudur and Cheri X. Deng PLoS One. 2013 Dec 12;8(12):e82689. doi: 10.1371/journal.pone.0082689. eCollection 2013. | Isolated heart (dog) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis. Angel J. de la Rosa, Jorge N. Domínguez, David Sedmera, Bara Sankova, Leif Hove-Madsen, Diego Franco and Amelia E. Aránega Cardiovasc Res. 2013 Jun 1;98(3):504-14. doi: 10.1093/cvr/cvt076. Epub 2013 Mar 29. | Isolated heart (mouse embryo) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Jeffrey R. Erickson, Laetitia Pereira, Lianguo Wang, Guanghui Han, Amanda Ferguson, Khanha Dao, Ronald J. Copeland, Florin Despa, Gerald W. Hart, Crystal M. Ripplinger and Donald M. Bers Nature. 2013 Oct 17;502(7471):372-6. doi: 10.1038/nature12537. Epub 2013 Sep 29. | Isolated heart (rat) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Multi-Stage Electrotherapy Delivered Through Chronically Implanted Leads Terminates Atrial Fibrillation with Lower Energy than a Single Biphasic Shock. Ajit H. Janardhan, Sarah R. Gutbrod, Wenwen Li, Di Lang, Richard B. Schuessler and Igor R. Efimov J Am Coll Cardiol. 2013 Sep 26. pii: S0735-1097(13)05356-4. doi: 10.1016/j.jacc.2013.07.098. [Epub ahead of print] | Isolated heart (dog) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Sinoatrial node reentry in a canine chronic left ventricular infarct model: role of intranodal fibrosis and heterogeneity of refractoriness. Alexey V. Glukhov, Lori T. Hage, Brian J. Hansen, Adriana Pedraza-Toscano, Pedro Vargas-Pinto, Robert L. Hamlin, Raul Weiss, Cynthia A. Carnes, George E. Billman and Vadim V. Fedorov Circ Arrhythm Electrophysiol. 2013 Oct 1;6(5):984-94. doi: 10.1161/CIRCEP.113.000404. Epub 2013 Aug 19. | Isolated heart (dog) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA |
| Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1. Dolkun Rahmutula, Gregory M. Marcus, Emily E. Wilson, Chun-Hua Ding, Yuanyuan Xiao, Agnes C. Paquet, Rebecca Barbeau, Andrea J. Barczak, David J. Erle and Jeffrey E. Olgin Cardiovasc Res. 2013 Sep 1;99(4):769-79. doi: 10.1093/cvr/cvt074. Epub 2013 Apr 23. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Functional roles of KATP channel subunits in metabolic inhibition. Alexey V. Glukhova, Keita Uchida, Igor R. Efimov, Colin G. Nichols J Mol Cell Cardiol. 2013 Apr 23;62C:90-98. doi: 10.1016/j.yjmcc.2013.04.016. [Epub ahead of print] | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Mesenchymal Stem Cell Transplantation Mitigates Electrophysiological Remodeling in a Rat Model of Myocardial Infarction. Patrick F.H. Lai, Brian K. Panama, Stéphane Massé, Guangming Li, Yaoguang Zhang, Marjan Kusha, Talha A. Farid, John Asta, Peter H. Backx, Terrence M. Yau and Kumaraswamy Nanthakumar J Cardiovasc Electrophysiol. 2013 Apr 8. doi: 10.1111/jce.12162. [Epub ahead of print] | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA (dual camera) |
| Calcium measurements from whole heart using Rhod-2. Bum-Rak Choi Methods Mol Biol. 2013;937:217-28. | Isolated heart (rabbit, guinea pig, mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium. Grazia Ammirabile, Alessandra Tessari, Viviana Pignataro, Dorota Szumska, Fabio Sutera Sardo, Jiri Benes, Jr, Mariangela Balistreri, Shoumo Bhattacharya, David Sedmera and Marina Campione Cardiovasc Res. 2012 Feb 1;93(2):291-301. doi: 10.1093/cvr/cvr314. Epub 2011 Nov 23. | Isolated heart (mouse embryo) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| The effect of connexin40 deficiency on ventricular conduction system function during development. Barbora Sankova, Jiri Benes Jr, Eliska Krejci, Laurent Dupays, Magali Theveniau-Ruissy, Lucile Miquerol and David Sedmera Cardiovasc Res. 2012 Sep 1;95(4):469-79. doi: 10.1093/cvr/cvs210. Epub 2012 Jun 27. | Isolated heart (embryo) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Identification and Functional Characterization of Cardiac Pacemaker Cells in Zebrafish. Federico Tessadori, Jan Hendrik van Weerd, Silja B. Burkhard, Arie O. Verkerk, Emma de Pater, Bastiaan J. Boukens, Aryan Vink, Vincent M. Christoffels and Jeroen Bakkers PLoS One. 2012;7(10):e47644. doi: 10.1371/journal.pone.0047644. Epub 2012 Oct 16. | Isolated heart (zebrafish) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes. Jacob I Laughner, Fu Siong Ng, Matthew S Sulkin, R Martin Arthur and Igor R Efimov Am J Physiol Heart Circ Physiol. 2012 Oct;303(7):H753-65. doi: 10.1152/ajpheart.00404.2012. Epub 2012 Jul 20. | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts. Ya-Jian Cheng, Di Lang, Shelton D Caruthers, Igor R Efimov, Junjie Chen and Samuel A Wickline Am J Physiol Heart Circ Physiol. 2012 Sep 1;303(5):H559-68. doi: 10.1152/ajpheart.00321.2012. Epub 2012 Jul 9. | Isolated heart (mouse) | CaSD (Rhod-2 AM) | MiCAM ULTIMA |
| Oscillation in Cycle Length Induces Transient Discordant and Steady-State Concordant Alternans in the Heart. Seth H. Weinberg and Leslie Tung PLoS One. 2012;7(7):e40477. Epub 2012 Jul 5. | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) CaSD (Rhod-2 AM) | MiCAM ULTIMA |
| Construction of 3D MR image-based computer models of pathologic hearts, augmented with histology and optical fluorescence imaging to characterize action potential propagation. Mihaela Pop, Maxime Sermesant, Garry Liu, Jatin Relan, Tommaso Mansi, Alan Soong, Jean-Marc Peyrat, Michael V. Truong, Paul Fefer, Elliot R. McVeigh, Herve Delingette, Alexander J. Dick, Nicholas Ayache, Graham A. Wright Med Image Anal. 2012 Feb;16(2):505-23. Epub 2011 Dec 6. | Isolated heart (pig) | VSD (Di-4-ANEPPS) | MiCAM02 (dual camera) |
| Conduction and refractory disorders in the diabetic atrium. Masaya Watanabe, Hisashi Yokoshiki, Hirofumi Mitsuyama, Kazuya Mizukami, Taisuke Ono, and Hiroyuki Tsutsui Am J Physiol Heart Circ Physiol. 2012 Jul;303(1):H86-95. Epub 2012 May 4. | Isolated heart (rat) | VSD (Di-4-ANEPPS) | MiCAM02 |
| Local β-Adrenergic Stimulation Overcomes Source-Sink Mismatch to Generate Focal Arrhythmia. Rachel C. Myles, Lianguo Wang, Chaoyi Kang, Donald M. Bers and Crystal M. Ripplinger Circ Res. 2012 May 25;110(11):1454-64. Epub 2012 Apr 26. | Isolated heart (rabbit) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias. Aneesh Bapat, Thao P. Nguyen, Jong-Hwan Lee Ali A. Sovari, Michael C. Fishbein, James N. Weiss and Hrayr S. Karagueuzian Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2331-40. Epub 2012 Mar 30. | Isolated heart (rat) | VSD (RH-237) | MiCAM ULTIMA |
| A Novel, Minimally Invasive, Segmental Myocardial Infarction with a Clear Healed Infarct Borderzone in Rabbits. Ohad Ziv, Lorraine Schofield, Emily Lau, Leonard Chaves, Dyviang Patel, Paul Jeng, Xuwen Peng, Bum-Rak Choi and Gideon Koren Am J Physiol Heart Circ Physiol. 2012 Mar 23. [Epub ahead of print] | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy. Alexey V. Glukhov, Vadim V. Fedorov, Paul W. Kalish, Vinod K. Ravikumar, Qing Lou, Deborah Janks, Richard B. Schuessler, Nader Moazami and Igor R. Efimov Circulation. 2012 Apr 17;125(15):1835-47. Epub 2012 Mar 12. | Isolated heart (dog and human) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Three Potential Mechanisms for Failure of HIFU Ablation in Cardiac Tissue. Jacob I. Laughner, Matthew S. Sulkin, Ziqi Wu, Cheri X. Deng and Igor R. Efimov Circ Arrhythm Electrophysiol. 2012 Feb 9. [Epub ahead of print] | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Inter-model consistency and complementarity: Learning from ex-vivo imaging and electrophysiological data towards an integrated understanding of cardiac physiology. O. Camara, M. Sermesant, P. Lamata, L. Wang,M. Pop, J. Relan, M. De Craene, H. Delingette, H. Liu, S. Niederer, A. Pashaei, G. Plank, D. Romero R. Sebastian, K.C.L. Wong, H. Zhang, N. Ayache, A.F. Frangi, P. Shi, N.P. Smith G.A. Wright Prog Biophys Mol Biol. 2011 Oct;107(1):122-33. Epub 2011 Jul 20. | Isolated heart (pig) | VSD (Di-4-ANEPPS) | MiCAM02 (dual camera) |
| Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. Paulus Kirchhof, Eloi Marijond, Larissa Fabritza, Na Li, Wei Wang, Tiannan Wang, Kirsten Schulte, Juliane Hanstein, Jan S. Schulte, Mathis Vogel, Nathalie Mougenot, Sandra Laakmann, Lisa Fortmueller, Jens Eckstein, Sander Verheule, Sven Kaese, Ariane Staab, Stephanie Grote-Wessels, Ulrich Schotten, Ghassan Moubarak, Xander H.T. Wehrens, Wilhelm Schmitz, Stéphane Hatem, Frank Ulrich Müller. Int J Cardiol. 2011 Nov 15. [Epub ahead of print] | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. Stacey Rentschler, Brett S. Harris, Laura Kuznekoff, Rajan Jain, Lauren Manderfield, Min Min Lu, Gregory E. Morley, Vickas V. Patel and Jonathan A. Epstein J Clin Invest. 2011 Feb;121(2):525-33. doi: 10.1172/JCI44470. Epub 2011 Jan 25. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Transmural Heterogeneity and Remodeling of Ventricular Excitation-Contraction Coupling in Human Heart Failure. Qing Lou, Vadim V. Fedorov, Alexey V. Glukhov, Nader Moazami, Vladimir G. Fast and Igor R. Efimov Circulation. 2011 May 3;123(17):1881-90. Epub 2011 Apr 18. | Isolated heart (human) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Spatiotemporal control of heart rate in a rabbit heart. Di Lang, Valentin Petrov, Qing Lou, Grigory Osipov and Igor R. Efimov J Electrocardiol. 2011 Nov-Dec;44(6):626-34. Epub 2011 Sep 19. | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias. Benjamin F. Remo, Jiaxiang Qu, Frank M. Volpicelli, Steven Giovannone, Daniel Shin, Joshua Lader, Fang-yu Liu, Jie Zhang, Danielle S. Lent, Gregory E. Morley and Glenn I. Fishman Circ Res. 2011 Jun 10;108(12):1459-66. Epub 2011 Apr 28. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Anatomic localization and autonomic modulation of atrioventricular junctional rhythm in failing human hearts. Vadim V. Fedorov, Christina M. Ambrosi, Geran Kostecki, William J. Hucker, Alexey V. Glukhov, Joseph P. Wuskell, Leslie M. Loew, Nader Moazami and Igor R. Efimov Circ Arrhythm Electrophysiol. 2011 Aug 1;4(4):515-25. Epub 2011 Jun 6. | Isolated heart (human) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA (dual camera) |
| Role of Pyk2 in cardiac arrhythmogenesis. Di Lang, Alexey V. Glukhov, Tatiana Efimova and Igor R. Efimov Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H975-83. Epub 2011 Jun 10. | Isolated heart (mouse) | VSD (RH-237) | MiCAM ULTIMA |
| Spatiotemporal electrophysiological changes in a murine ablation model. Scott A. Bernstein, Srikant Duggirala, Michael Floberg, Pehr Elfvendal, Laura M. Kuznekoff, Joshua M. Lader, Carolina Vasquez and Gregory E. Morley Europace. 2011 Oct;13(10):1494-500. Epub 2011 Jun 28. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| In-vitro recording of adult zebrafish heart electrocardiogram - a platform for pharmacological testing. Chia-Ti Tsai, Cho-Kai Wu, Fu-Tien Chiang, Chuen-Den Tseng, Jen-Kuang Lee, Chih-Chieh Yu, Yi-Chih Wang, Ling-Ping Lai, Jiunn-Lee Lin and Juey-Jen Hwang Clin Chim Acta. 2011 Oct 9;412(21-22):1963-7. Epub 2011 Jul 8. | Isolated heart (zebrafish) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Remodeling of atrial ATP-sensitive K+ channels in a model of salt-induced elevated blood pressure. Joshua M. Lader, Carolina Vasquez, Li Bao, Karen Maass, Jiaxiang Qu, Eirini Kefalogianni, Glenn I. Fishman, William A. Coetzee and Gregory E. Morley Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H964-74. Epub 2011 Jul 1. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. Vadim V. Fedorov, Alexey V. Glukhov, Christina M. Ambrosi, Geran Kostecki, Roger Chang, Deborah Janks, Richard B. Schuessler, Nader Moazami, Colin G. Nichols and Igor R. Efimov J Mol Cell Cardiol. 2011 Aug;51(2):215-25. Epub 2011 May 7. | Isolated heart (human) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA (dual camera) |
| Multiparametric Optical Mapping of the Langendorff-perfused Rabbit Heart (Video Article). Qing Lou, Wenwen Li and Igor R. Efimov J. Vis. Exp. (55), e3160, DOI: 10.3791/3160 (2011) | Isolated heart (rabbit) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Optical Mapping of Action Potentials and Calcium Transients in the Mouse Heart (Video Article). Di Lang, Matthew Sulkin, Qing Lou and Igor R. Efimov J. Vis. Exp. (55), e3275, DOI: 10.3791/3275 (2011) | Isolated heart (mouse) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles. Su-Kiat Chua, Po-Cheng Chang, Mitsunori Maruyama, Isik Turker, Tetsuji Shinohara, Mark J. Shen, Zhenhui Chen, Changyu Shen, Michael Rubart-von der Lohe, John C. Lopshire, Masahiro Ogawa, James N. Weiss, Shien-Fong Lin, Tomohiko Ai and Peng-Sheng Chen Circ Res. 2011 Apr 15;108(8):971-9. Epub 2011 Feb 24. | Isolated heart (rabbit) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice. Mitsunori Maruyama, Bai-Yan Li, Hanying Chen, Xuehong Xu, Long-Sheng Song, Silvia Guatimosim, Wuqiang Zhu, Weidong Yong, Wenjun Zhang, Guixue Bu, Shien-Fong Lin, Michael C. Fishbein, W. Jonathan Lederer, John H. Schild, Loren J. Field, Michael Rubart, Peng-Sheng Chen and Weinian Shou Circ Res. 2011 Apr 29;108(9):1042-52. Epub 2011 Mar 3. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA (dual camera) |
| Intracellular calcium and the mechanism of anodal supernormal excitability in langendorff perfused rabbit ventricles. Boyoung Joung, Hyung-Wook Park, Mitsunori Maruyama, Liang Tang, Juan Song, Seongwook Han, Gianfranco Piccirillo, James N. Weiss, Shien-Fong Lin and Peng-Sheng Chen Circ J. 2011 Apr;75(4):834-43. Epub 2011 Feb 2. | Isolated heart (rabbit) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Delayed afterdepolarization in intact canine sinoatrial node as a novel mechanism for atrial arrhythmia. Boyoung Joung, Hong Zhang, Tetsuji Shinohara, Mitsunori Maruyama, Seongwook Han, Daehyeok Kim, Eue-Keun Choi, Young-Keun On, Shien-Fong Lin and Peng-Sheng Chen J Cardiovasc Electrophysiol. 2011 Apr;22(4):448-54. doi: 10.1111/j.1540-8167.2010.01905.x. Epub 2010 Oct 6. | Isolated heart (dog) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Genesis of phase 3 early afterdepolarizations and triggered activity in acquired long-QT syndrome. Mitsunori Maruyama, Shien-Fong Lin, Yuanfang Xie, Su-Kiat Chua, Boyoung Joung, Seongwook Han, Tetsuji Shinohara, Mark J. Shen, Zhilin Qu, James N. Weiss and Peng-Sheng Chen Circ Arrhythm Electrophysiol. 2011 Feb;4(1):103-11. Epub 2010 Nov 15. | Isolated heart (rabbit) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Personalisation of a Cardiac Electrophysiology Model using Optical Mapping and MRI for Prediction of Changes with Pacing. Jatin Relan, Mihaela Pop, H Delingette, G Wright, N Ayache and M Sermesant IEEE Trans Biomed Eng. 2011 Jan 20. [Epub ahead of print] | Isolated heart (pig) | VSD (Di-4-ANEPPS) | MiCAM02 (dual camera) |
| The role of the calcium and the voltage clocks in sinoatrial node dysfunction. Boyoung Joung, Peng-Sheng Chen and Shien-Fong Lin Yonsei Med J. 2011 Mar 1;52(2):211-9. | Isolated heart (dog) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Assessment of cardiac conduction: basic principles of optical mapping. Chunhua Ding and Thomas H. Everett Methods Mol Biol. 2010;660:239-52. | Isolated heart (mouse) | VSD (Di-4-ANEPPS or PGH-I) | MiCAM02 |
| PITX2c is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene Expression. Paulus Kirchhof, Peter C. Kahr, Sven Kaese, Ilaria Piccini, Ismail Vokshi, Hans-Heinrich Scheld, Heinrich Rotering, Lisa Fortmueller, Sandra Laakmann, Sander Verheule, Ulrich Schotten, Larissa Fabritz and Nigel A. Brown Circ Cardiovasc Genet. 2011 Apr;4(2):123-33. Epub 2011 Jan 31. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Alternans of diastolic intracellular calcium elevation as the mechanism of bidirectional ventricular tachycardia in a rabbit model of Andersen-Tawil syndrome. Mitsunori Maruyama, Shien-Fong Lin and Peng-Sheng Chen Heart Rhythm. 2010 Dec 15. [Epub ahead of print] | Isolated heart (rabbit) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Ca2+ clock malfunction in a canine model of pacing-induced heart failure. Tetsuji Shinohara, Hyung-Wook Park, Seongwook Han, Mark J. Shen, Mitsunori Maruyama, Daehyeok Kim, Peng-Sheng Chen and Shien-Fong Lin Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1805-11. Epub 2010 Oct 1. | Isolated heart (dog) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Calcium dynamics and the mechanisms of atrioventricular junctional rhythm. Daehyeok Kim, Tetsuji Shinohara, Boyoung Joung, Mitsunori Maruyama, Eue-Keun Choi, Young Keun On, Seongwook Han, Michael C. Fishbein, Shien-Fong Lin and Peng-Sheng Chen J Am Coll Cardiol. 2010 Aug 31;56(10):805-12. | Isolated heart (mongrel dog) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Tachybradycardia in the isolated canine right atrium induced by chronic sympathetic stimulation and pacemaker current inhibition. Boyoung Joung, Tetsuji Shinohara, Hong Zhang, Daehyeok Kim, Eue-Keun Choi, Yong-Keun On, Gianfranco Piccirillo, Peng-Sheng Chen and Shien-Fong Lin Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H634-42. Epub 2010 Jul 2. | Isolated heart (dog) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome. Przemysław B. Radwański, Rengasayee Veeraraghavan and Steven Poelzing Heart Rhythm. 2010 Oct;7(10):1428-1435.e1. Epub 2010 Apr 7. | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) CaSD (Indo-1) | MiCAM02 (dual camera) |
| Anatomy and electrophysiology of the human AV node. Thomas Kurian, Christina Ambrosi, William Hucker, Vadim V. Fedorov and Igor R. Efimov Pacing Clin Electrophysiol. 2010 Jun 1;33(6):754-62. Epub 2010 Feb 18. | Isolated heart (human) | VSD | MiCAM ULTIMA |
| In vivo assessment of the electrophysiological integration and arrhythmogenic risk of myocardial cell transplantation strategies. Lior Gepstein, Chunhua Ding, Dolkun Rehemedula, Emily E. Wilson, Lior Yankelson, Oren Caspi, Amira Gepstein, Irit Huber and Jeffery E. Olgin Stem Cells. 2010 Dec;28(12):2151-61. | Isolated heart (rat) | VSD (PGH I) | MiCAM02 (dual camera) |
| Termination of sustained atrial flutter and fibrillation using low-voltage multiple-shock therapy. Christina M. Ambrosi, Crystal M. Ripplinger, Igor R. Efimov and Vadim V. Fedorov Heart Rhythm. 2011 Jan;8(1):109-10. | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Optical mapping of the isolated coronary-perfused human sinus node. Vadim V. Fedorov, Alexey V. Glukhov, Roger Chang, Geran Kostecki, Hyuliya Aferol, William J. Hucker, Joe Wuskell, Leslie M. Loew, Richard B. Schuessler, Nader Moazami and Igor R. Efimov J Am Coll Cardiol. 2010 Oct 19;56(17):1386-94. | Isolated heart (human) | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA |
| ST segment elevation by current-to-load mismatch: an experimental and computational study. Mark G. Hoogendijk, Mark Potse, Alain Vinet, Jacques M.T. de Bakker and Ruben Coronel Heart Rhythm. 2011 Jan;8(1):111-8. Epub 2010 Oct 30. | Isolated heart (pig) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability. Andreas Blana, Sven Kaese, Lisa Fortmüller, Sandra Laakmann, Dierk Damke, Kelly van Bragt, Jens Eckstein, Ilaria Piccini, Uwe Kirchhefer, Stanley Nattel, Günter Breithardt, Peter Carmeliet, Edward Carmeliet, Ulrich Schotten, Sander Verheule, Paulus Kirchhof and Larissa Fabritz Heart Rhythm. 2010 Dec;7(12):1862-9. Epub 2010 Aug 19. | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Complex interactions between the sinoatrial node and atrium during reentrant arrhythmias in the canine heart. Vadim V. Fedorov, Roger Chang, Alexey V. Glukhov, Geran Kostecki, Deborah Janks, Richard B. Schuessler and Igor R. Efimov Circulation. 2010 Aug 24;122(8):782-9. Epub 2010 Aug 9. | Isolated heart (mongrel dog) | VSD (Di-4-ANEPPS or RH-237) | MiCAM ULTIMA |
| Functional anatomy of the murine sinus node: high-resolution optical mapping of ankyrin-B heterozygous mice. Alexey V. Glukhov, Vadim V. Fedorov, Mark E. Anderson, Peter J. Mohler and Igor R. Efimov Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H482-91. Epub 2010 Jun 4. | Isolated heart (mouse) | VSD (RH-237) | MiCAM ULTIMA |
| Differential K(ATP) channel pharmacology in intact mouse heart. Alexey V. Glukhov, Thomas P. Flagg, Vadim V. Fedorov, Igor R. Efimov and Colin G. Nichols J Mol Cell Cardiol. 2010 Jan;48(1):152-60. Epub 2009 Sep 8. | Isolated heart (mouse) | VSD (RH-237) | MiCAM ULTIMA |
| Electrophysiological Studies of Transgenic Long QT Type 1 and 2 Rabbits Reveal Genotype-Specific Differences in Ventricular Refractoriness and His Conduction. Katja E. Odening, Malcolm Kirk, Michael Brunner, Ohad Ziv, Peem Lorvidhaya, Gong Xin Liu, Lorraine Schofield, Leonard Chaves, Xuwen Peng, Manfred Zehender, Bum-Rak Choi and Gideon Koren Am J Physiol Heart Circ Physiol. 2010 Jun 25. [Epub ahead of print] | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Transmural dispersion of repolarization in failing and nonfailing human ventricle. Alexey V. Glukhov, Vadim V. Fedorov, Qing Lou, Vinod K. Ravikumar, Paul W. Kalish, Richard B. Schuessler, Nader Moazami and Igor R. Efimov Circ Res. 2010 Mar 19;106(5):981-91. Epub 2010 Jan 21. | Isolated heart (human) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Electrical Activation of Sinus Venosus Myocardium and Expression Patterns of RhoA and Isl-1 in the Chick Embryo. Rebecca Vicente-Steijn, Denise P. Kolditz, Edris A.F. Mahtab, Saïd F.A. Askar, Noortje A.M. Bax, Linda M. Van Der Graaf, Lambertus J. Wisse, Robert Passier, Daniël A. Pijnappels, Martin J. Schalij, Robert E. Poelmann, Adriana C. Gittenberger-De Groot and Monique R.M. Jongbloed J Cardiovasc Electrophysiol. 2010 Apr 29. [Epub ahead of print] | Isolated heart (chick embryo) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Pharmacological Activation of IKr Impairs Conduction in Guinea Pig Hearts. Anders Peter Larsen, Søren-Peter Olesen, Morten Grunnet and Steven Poelzing J Cardiovasc Electrophysiol. Published Online: Feb 16 2010 | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM02 (dual camera) |
| High-resolution optical mapping of ventricular tachycardia in rats with chronic myocardial infarction. Chunhua Ding, Lior Gepstein, Duy Thai Nguyen, Emily Wilson, George Hulley, Andrew Beaser, Randall J. Lee and Jeffrey Olgin Pacing Clin Electrophysiol. 2010 Jun 1;33(6):687-95. | Isolated heart (rat) | VSD (PGH I) | MiCAM02 |
| Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias. Duy T. Nguyen, Chunhua Ding, Emily Wilson, Gregory M. Marcus and Jeffrey E. Olgin Heart Rhythm. 2010 Apr 27. | Isolated heart (rat) | VSD | MiCAM ULTIMA |
| Effects of mechanical loading on early conduction system differentiation in the chick. Barbora Sankova, Jakub Machalek and David Sedmera Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1571-6. | Isolated heart (chick embryo) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Mapping cardiac pacemaker circuits: methodological puzzles of the sinoatrial node optical mapping. Igor R. Efimov, Vadim V. Fedorov, Boyoung Joung and Shien-Fong Lin Circ Res. 2010 Feb 5;106(2):255-71. | Isolated heart (rabbit, dog) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Transmural Dispersion of Repolarization in Failing and Nonfailing Human Ventricle. Alexey V. Glukhov, Vadim V. Fedorov, Qing Lou, Vinod K. Ravikumar, Paul W. Kalish, Richard B. Schuessler, Nader Moazami and Igor R. Efimov Circ Res.2010; 0: | Isolated heart (human) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Induction of atrial ectopic beats with calcium release inhibition: Local hierarchy of automaticity in the right atrium. Tetsuji Shinohara, Boyoung Joung, Daehyeok Kim, Mitsunori Maruyama, Hsiang-Ning Luk, Peng-Sheng Chen and Shien-Fong Lin Heart Rhythm. 2010 Jan;7(1):110-116 | Isolated heart (mongrel dog) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome. Ohad Ziv, Eduardo Morales, Yoon-kyu Song, Xuwen Peng, Katja E Odening, Alfred E Buxton, Alain Karma, Gideon Koren and Bum-Rak Choi J Physiol. 2009 Oct 1;587(Pt 19):4661-80. | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Diastolic Intracellular Calcium-Membrane Voltage Coupling Gain and Postshock Arrhythmias. Role of Purkinje Fibers and Triggered Activity. Mitsunori Maruyama, Boyoung Joung, Liang Tang, Tetsuji Shinohara, Young-Keun On, Seongwook Han, Eue-Keun Choi, Dae-Hyeok Kim, Mark J. Shen, James N. Weiss, Shien-Fong Lin and Peng-Sheng Chen Circ Res. 2010 Feb 5;106(2):399-408. Epub 2009 Nov 19. | Isolated heart (rabbit) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Optical mapping of VF in isolated swine hearts with scars. Mihaela Pop, Alan Soong, John M. Hudson, Paul Fefer, Alexander Dick and Graham A. Wright Biophysical Journal, Volume 96, Issue 3, Pages 262a-262a | Isolated heart (pig) | VSD (Di-4-ANEPPS) | MiCAM02 |
| Mechanisms of sinoatrial node dysfunction in a canine model of pacing-induced atrial fibrillation. Boyoung Joung, Shien-Fong Lin, Zhenhui Chen, Patrick S. Antoun, Mitsunori Maruyama, Seongwook Han, Gianfranco Piccirillo, Marcelle Stucky, Douglas P. Zipes, FHRS, Peng-Sheng Chen and Mithilesh Kumar Das> Heart Rhythm. 2010 Jan;7(1):88-95. Epub 2009 Sep 16. | Isolated heart (dog) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Gap junction remodeling and spironolactone-dependent reverse remodeling in the hypertrophied heart. Jiaxiang Qu, Frank M. Volpicelli, Luis I. Garcia, Nefthi Sandeep, Jie Zhang, Lucrecia Márquez-Rosado, Paul D. Lampe and Glenn I. Fishman | Isolated heart (mouse) | VSD | MiCAM ULTIMA |
| Simultaneous optical mapping of intracellular free calcium and action potentials from Langendorff perfused hearts. Guy Salama and Seong-min Hwang Curr Protoc Cytom. 2009 Jul;Chapter 12:Unit 12.17. | Isolated heart (guinea pig) | VSD (PGH I) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Inhomogeneous distribution of action potential characteristics in the rabbit sino-atrial node revealed by voltage imaging. Haruko Masumiya, Yoshitaka Oku and Yasumasa Okada J Physiol Sci. 2009 May;59(3):227-41. | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Fusion of optical imaging and MRI for the evaluation and adjustment of macroscopic models of cardiac electrophysiology: a feasibility study. Mihaela Pop, Maxime Sermesant, Damien Lepiller, Michael V. Truong, Elliot R. McVeigh, Eugene Crystal, Alexander Dick, Herve Delingette, Nicholas Ayache and Graham A. Wright Med Image Anal. 2009 Apr;13(2):370-80. | Isolated heart (pig) | VSD (Di-4-ANEPPS) | MiCAM02 (dual camera) |
| Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation. Boyoung Joung, Liang Tang, Mitsunori Maruyama, Seongwook Han, Zhenhui Chen, Marcelle Stucky, Larry R. Jones, Michael C. Fishbein, James N. Weiss, Peng-Sheng Chen and Shien-Fong Lin Circulation. 2009 Feb 17;119(6):788-96. | Isolated heart (mongrel dog) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Cardioprotective effects of propofol in isolated ischemia-reperfused guinea pig hearts: role of KATP channels and GSK-3beta. Noriko Kamada, Noriaki Kanaya, Naoyuki Hirata, Saori Kimura and Akiyoshi Namiki Can J Anaesth. 2008 Sep;55(9):595-605. | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM02 |
| Superiority of biphasic over monophasic defibrillation shocks is attributable to less intracellular calcium transient heterogeneity. Gyo-Seung Hwang, Liang Tang, Boyoung Joung, Norishige Morita, Hideki Hayashi, Hrayr S. Karagueuzian, James N. Weiss, Shien-Fong Lin and Peng-Sheng Chen J Am Coll Cardiol. 2008 Sep 2;52(10):828-35. | Isolated heart (rabbit) | VSD (RH-237) CaSD (Rhod-2 AM) | MiCAM ULTIMA (dual camera) |
| Abnormal Myocardial and Coronary Vasculature Development in Experimental Pypoxia. Ondrej Nanka, Petra Krizova, Michal Fikrle, Michal Tuma, Milan Blaha, Milos Grim and David Sedmera Anat Rec (Hoboken). 2008 Oct;291(10):spc1. | Isolated embryonic heart (Japanese quail) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Connexin40 Imparts Conduction Heterogeneity to Atrial Tissue. David E. Leaf, Jonathan E. Feig, Carolina Vasquez, Pamela L. Riva, Cindy Yu, Joshua M. Lader, Andrianos Kontogeorgis, Elvera L. Baron, Nicholas S. Peters, Edward A. Fisher, David E. Gutstein and Gregory E. Morley Circ Res. 2008 Jul 3. [Epub ahead of print] | Isolated heart (mouse) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Burst Emergence of Intracellular Ca2+ Waves Evokes Arrhythmogenic Oscillatory Depolarization via the Na+-Ca2+ Exchanger Simultaneous Confocal Recording of Membrane Potential and Intracellular Ca2+ in the Heart Katsuji Fujiwara, Hideo Tanaka, Hiroki Mani, Takuo Nakagami and Tetsuro Takamatsu Circ Res. 2008 Aug 29;103(5):509-18. Epub 2008 Jul 17. | Isolated heart (rat) | VSD (RH-237) CaSD (Fluo-4) | MiCAM02 |
| Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome Michael Brunner, Xuwen Peng, Gong Xin Liu, Xiao-Qin Ren, Ohad Ziv, Bum-Rak Choi, Rajesh Mathur, Mohammed Hajjiri, Katja E. Odening, Eric Steinberg, Eduardo J. Folco, Ekatherini Pringa, Jason Centracchio, Roland R. Macharzina, Tammy Donahay, Lorraine Schofield, Naveed Rana, Malcolm Kirk, Gary F. Mitchell, Athena Poppas, Manfred Zehender and Gideon Koren J Clin Invest. 2008 June 2; 118(6): 2246?2259. | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Mechanisms underlying increased right ventricular conduction sensitivity to flecainide challenge Rengasayee Veeraraghavan and Steven Poelzing Cardiovasc Res. 2008 Mar 1;77(4):749-56. | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM02 (dual camera) |
| An Experimental Framework to Validate 3D Models of Cardiac Electrophysiology Via Optical Imaging and MRI Mihaela Pop, Maxime Sermesant, Desmond Chung, Garry Liu, Elliot R. McVeigh, Eugene Crystal and Graham A. Wright Lecture Notes in Computer Science Publisher Springer Berlin / Heidelberg Volume 4466/2007; pages 100-109. | Isolated heart (pig) | VSD (Di-4-ANEPPS) | MiCAM02 (dual camera) |
| Imaging ventricular fibrillation. Guy Salama and Bum-Rak Choi J Electrocardiol. 2007 Nov-Dec;40:S56-61. | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation. Bum-Rak Choi, Woncheol Jang and Guy Salama Heart Rhythm. 2007 August; 4(8): 1057-1068. | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia. Wilhelm Roell, Thorsten Lewalter, Philipp Sasse, Yvonne N. Tallini, Bum-Rak Choi, Martin Breitbach, Robert Doran, Ulrich M. Becher, Seong-Min Hwang, Toktam Bostani, Julia von Maltzahn, Andreas Hofmann, Shaun Reining, Britta Eiberger, Bethann Gabris, Alexander Pfeifer, Armin Welz, Klaus Willecke, Guy Salama, Jan W. Schrickel, Michael I. Kotlikoff and Bernd K. Fleischmann Nature. 2007 Dec 6;450(7171):819-24. | In VIvo heart (mouse) | GGCaMP2 | MiCAM ULTIMA |
| Optical Mapping of Langendorff Perfused Human Hearts: Establishing a Model for the Study of Ventricular Fibrillation in Humans. Kumaraswamy Nanthakumar, José Jalife, Stéphane Massé, Eugene Downar, Mihaela Pop, John Asta, Heather Ross, Vivek Rao, Sergey Mironov, Elias Sevaptsidis, Jack Rogers, Graham Wright and Rajesh Dhopeshwarkar Am J Physiol Heart Circ Physiol. 2007 Mar 16; | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA MiCAM02 |
| Heterogeneous ventricular chamber response to hypokalemia and inward rectifier potassium channel blockade underlies bifurcated T wave in guinea pig. Steven Poelzing and Rengasayee Veeraraghavan Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3043-51. | Isolated heart (guinea pig) | VSD (Di-4-ANEPPS) | MiCAM02 (dual camera) |
| Stereo Reconstruction of the Epicardium for Optical Fluorescence Imaging. Desmond Chung, Mihaela Pop, Maxime Sermesant and Graham A. Wright MICCAI 2006 Workshop on Biophotonics Imaging for Diagnostics and Treatment. 2006 October 6; P33-40. | Isolated heart (pig) | VSD (Di-4-ANEPPS) | MiCAM02 (dual camera) |
| Pulsatile cardiac tissue grafts using a novel three-dimensional cell sheet manipulation technique functionally integrates with the host heart, in vivo. Akira Furuta, Shunichiro Miyoshi, Yuji Itabashi, Tatsuya Shimizu, Shinichiro Kira, Keiko Hayakawa, Nobuhiro Nishiyama, Kojiro Tanimoto, Yoko Hagiwara, Toshiaki Satoh, Keiichi Fukuda, Teruo Okano and Satoshi Ogawa Circ Res. 2006 Mar 17;98(5):705-12. | Isolated heart Cell sheet (rat) | VSD (Di-4-ANEPPS) | MiCAM01 |
| Interactions between paced wavefronts and monomorphic ventricular tachycardia: implications for antitachycardia pacing. Israel A. Byrd, Matthew W. Kay and Andrew E. Pollard J Cardiovasc Electrophysiol. 2006 Oct;17(10):1129-39. | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM01 |
| Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2 Yvonne N. Tallini, Masamichi Ohkura, Bum-Rak Choi, Guangju Ji, Keiji Imoto, Robert Doran, Jane Lee, Patricia Plan, Jason Wilson, Hong-Bo Xin, Atsushi Sanbe, James Gulick, John Mathai, Jeffrey Robbins, Guy Salama, Junichi Nakai and Michael I. Kotlikoff Proc Natl Acad Sci USA. 2006 Mar 21;103(12):4753-8. Epub 2006 Mar 13. | In VIvo heart (mouse) | GCaMP2 | MiCAM ULTIMA |
| Properties of new, long-wavelength, voltage-sensitive dyes in the heart. Guy Salama, Bum-Rak Choi, Ghassan Azour, Mitra Lavasani, Vasil Tumbev, Brian M. Salzberg, Michael J. Patrick, Lauren A. Ernst and Alan S. Waggoner J Membr Biol. 2005 Nov;208(2):125-40. | Isolated heart (guinea pig, rabbit, mouse) | VSD (PGH I-VII) | MiCAM ULTIMA |
| Termination of spiral waves during cardiac fibrillation via shock-induced phase resetting. Richard A Gray and Nipon Chattipakorn PNAS. 2005 Mar 29;102(13):4672-7. | Isolated heart (pig) | VSD (Di-4-ANEPPS) | MiCAM01 |
| Optical Imaging of the Heart. Igor R. Efimov, Vladimir P. Nikolski and Guy Salama. Circulation Research 2004 Jul 9;95(1):21-33. | Isolated heart (guinea pig) | VSD | MiCAM ULTIMA |
| Three-dimensional surface reconstruction and panoramic optical mapping of large hearts. Matthew W Kay, Philip M Amison and Jack M Rogers IEEE Transactions on Biomedical Engineering, 2004 Jul;51(7):1219-29 | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM01 |
| Effect of shock-induced changes in transmembrane potential on reentrant waves and outcome during cardioversion of isolated rabbit hearts. Frederick G. Evans, Raymond E. Ideker and Richard A. Gray J Cardiovasc Electrophysiol. 2002 Nov;13(11):1118-27. | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM01 |
| Effect of Action Potential Duration and Conduction Velocity Restitution and Their Spatial Dispersionon Alternans and the Stability of Arrhythmias. Isabelle Banville and Richard A Gray. J Cardiovasc Electrophysiol. 2002 Nov;13(11):1141-9. | Isolated heart (rabbit) | VSD (Di-4-ANEPPS) | MiCAM01 |
| Anisotropic conduction properties in canine atria analyzed by high-resolution optical mapping: preferential direction of conduction block changes from longitudinal to transverse with increasing age. Takahiro Koura, Motoki Hara, Susumu Takeuchi, Kenichi Ota, Yasumasa Okada, Shunichiro Miyoshi, Atsushi Watanabe, Kazumi Shiraiwa, Hideo Mitamura, Itsuo Kodama and Satoshi Ogawa Circulation. 2002;105:2092 | Isolated atrial tissue | VSD (Di-4-ANEPPS) | MiCAM01 |
| Mechanism of Ventricular Defibrillation for Near-Defibrillation Threshold Shocks. Nipon Chattipakorn, Isabelle Banville, Richard A Gray and Raymond E Ideker. Circulation. 2001;104:1313. | Isolated heart (pig) | VSD (Di-4-ANEPPS) | MiCAM01 |
| Spatial and temporal organization during cardiac fibrillation. Richard A. Gray, Arkady M. Pertsov and Jose Jalife. Nature, 392, 75-78 (1998) | Isolated heart (rabbit, sheep) | VSD (Di-4-ANEPPS) | MiCAM01 |
培養心筋細胞
合計：75
| 論文名 | サンプル | 色素 | イメージングシステム |
|---|---|---|---|
| NaV1.5 knockout in iPSCs: a novel approach to study NaV1.5 variants in a human cardiomyocyte environment. Marion Pierre, Mohammed Djemai, Hugo Poulin, and Mohamed Chahine Sci Rep. 2021; 11: 17168. | Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) | VSD (Di-4-ANEPPS) CaSD (Rhod-2 AM) | MiCAM03 |
| High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias. Yayoi Honda, Jun Li, Aya Hino, Shinji Tsujimoto, and Jong-Kook Lee Front Pharmacol. 2021 Aug 3;12:680618. | Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) | VSD (FluoVolt) | MiCAM02 |
| Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC. Robert N. Hawthorne, Adriana Blazeski, Justin Lowenthal, Suraj Kannan, Roald Teuben, Deborah DiSilvestre, Justin Morrissette-McAlmon, Jeffrey E. Saffitz, Kenneth R. Boheler, Cynthia A. James, Stephen P. Chelko, Gordon Tomaselli and Leslie Tung J. Clin. Med. 2021, 10(14), 3061; | Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) | VSD (Di-4-ANEPPS) CaSD (Rhod-2 AM) | MiCAM ULTIMA |
| A 3-D Human Model of Complex Cardiac Arrhythmias. Kenneth Williams, Timothy Liang, Stéphane Massé, Safwat Khan, Rupal Hatkar, Gordon Keller, Kumaraswamy Nanthakumar, Sara S. Nunes Acta Biomaterialia Available online 10 March 2021 | Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) | CaSD | MiCAM ULTIMA |
| Human iPSC engineered cardiac tissue platform faithfully models important cardiac physiology. Willem J. de Lange, Emily T. Farrell, Caroline R. Kreitzer, Derek R. Jacobs, Di Lang, Alexey V. Glukhov, and J. Carter Ralphe Am J Physiol Heart Circ Physiol. 2021 Feb 19. | Human induced pluripotent stem cells (hiPSC-CM) | CaSD | MiCAM ULTIMA |
| Myocardial repair of bioengineered cardiac patches with decellularized placental scaffold and human-induced pluripotent stem cells in a rat model of myocardial infarction. Yu Jiang, Si-Jia Sun, Zhe Zhen, Rui Wei, Nannan Zhang, Song-Yan Liao & Hung-Fat Tse Stem Cell Res Ther 12, 13 (2021). | Bioengineered cardiac patch (human-induced pluripotent stem cell-derived cardiomyocytes: hiPSC-CMs) | CaSD (Fura-2 AM) | MiCAM ULTIMA |
| iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities. Hugo Poulin, Aurélie Mercier, Mohammed Djemai, Valérie Pouliot, Isabelle Deschenes, Mohamed Boutjdir, Jack Puymirat & Mohamed Chahine Scientific Reports volume 11, Article number: 2500 (2021) | Induced pluripotent stem-derived cardiomyocytes (iPSC-CMs) | VSD (Di-4-ANEPPS) | MiCAM03 |
| Scaffold-Mediated Developmental Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Are Preserved After External Support Removal. Jun Li, Jong-Kook Lee, Keiko Miwa, Yuki Kuramoto, Kiyoshi Masuyama, Hideki Yasutake, Satoki Tomoyama, Hiroyuki Nakanishi, and Yasushi Sakata Front Cell Dev Biol. 2021; 9: 591754. | Human induced pluripotent stem-derived cardiomyocytes (hiPSC-CMs) | VSD (FluoVolt) | MiCAM02 |
| Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues. Andy On-Tik Wong, Bimal Gurung, Wing Sum Wong, Suet Yee Mak, Wan Wai Tse, Chloe M. Li, Deborah K. Lieu, Kevin D. Costa, Ronald A. Li, and Roger J. Hajjar J Mol Cell Cardiol. 2021 Apr; 153: 106?110. | Human pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) | ? | MiCAM03 |
| Local hyperactivation of L-type Ca2+ channels increases spontaneous Ca2+ release activity and cellular hypertrophy in right ventricular myocytes from heart failure rats. Roman Y. Medvedev, Jose L. Sanchez-Alonso, Catherine A. Mansfield, Aleksandra Judina, Alice J. Francis, Christina Pagiatakis, Natalia Trayanova, Alexey V. Glukhov, Michele Miragoli, Giuseppe Faggian & Julia Gorelik Scientific Reports volume 11, Article number: 4840 (2021) | Isolated myocytes | CaSD (Fluo-4 AM) | MiCAM ULTIMA |
| Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium. Cassady E. Rupert, Tae Yun Kim, Bum-Rak Choi, and Kareen L. K. Coulombe Stem Cells Int. 2020; 2020: 9363809. | Engineered cardiac tissues | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity. Jessica M. Miller, Moustafa H. Meki, Qinghui Oua, Sharon A. George, Anna Gams, Riham R.E. Abouleisa, Xian-Liang Tang, Brooke M. Ahern, Guruprasad A. Giridharan, Ayman El-Baz, Bradford G. Hill, Jonathan Satin, Daniel J.Conklin, Javid Moslehi, Roberto Bolli, Alexandre J.S. Ribeiro, Igor R. Efimov, Tamer M.A. Mohamed Toxicology and Applied Pharmacology, Volume 406, 2020,115213 | Cultured heart slice | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts. B. N. Napiwocki, D. Lang, A. Stempien, J. Zhang, R. Vaidyanathan, J. C. Makielski, L. L. Eckhardt, A. V. Glukhov, T. J. Kamp, W. C. Crone Biotechnology and Bioengineering. 2021; 118: 442? 452. | Human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) | CaSD (Rhod-2 AM) | MiCAM ULTIMA |
| The proarrhythmic features of pathological cardiac hypertrophy in neonatal rat ventricular cardiomyocyte cultures Zeinab Neshati, Martin J Schalij, Antoine A F de Vries J Appl Physiol (1985). 2020 Mar 1;128(3):545-553. | Neonatal rat ventricular cardiomyocytes | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Adrenoceptor Responses in Human Embryonic Stem Cell-Derived Cardiomyocytes: a Special Focus on Electrophysiological Property. Weiwei Jiang, Xingjian Hu, Fei Li, Geng Li, Yin Wang J Pharmacol Exp Ther. 2020 Jun;373(3):429-437. | Human embryonic stem cell]derived cardiomyocytes (hESC-CMs) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Single]Cell Transcriptomics of Engineered Cardiac Tissues From Patient]Specific Induced Pluripotent Stem Cell?Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome. Yin]Yu Lam, Wendy Keung, Chun]Ho Chan, Lin Geng, Nicodemus Wong, David Brenière]Letuffe, Ronald A. Li and Yiu]Fai Cheung J Am Heart Assoc. 2020 Oct 20; 9(20): e016528. | Human cardiac anisotropic sheet | VSD (Di-8-ANEPPS) | MiCAM ULTIMA |
| Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation as Revealed by Optical Mapping of Action Potentials and Calcium Transients. Andy On-Tik Wong, Nicodemus Wong, Lin Geng, Maggie Zi-ying Chow, Eugene K. Lee, Hongkai Wu, Michelle Khine, Chi-Wing Kong, Kevin D. Costa, Wendy Keung, Yiu-Fai Cheung, and Ronald A. Li Front Physiol. 2020; 11: 165. | Human ventricular cardiac anisotropic sheet preparations | VSD (Di-8-ANEPPS) | MiCAM ULTIMA |
| Functional Properties of Engineered Heart Slices Incorporating Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Adriana Blazeski, Justin Lowenthal, Renjun Zhu, Jourdan Ewoldt, Kenneth R. Boheler, and Leslie Tung Theranostics. 2019; 9(24): 7222?7238. | Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variation. Sarkawt Hamad, Daniel Derichsweiler, Symeon Papadopoulos, Filomain Nguemo, Tomo Šarić, Agapios Sachinidis, Konrad Brockmeier, Jürgen Hescheler, Bastiaan J Boukens, and Kurt Pfannkuche Theranostics. 2019; 9(24): 7222?7238. | Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Engineered Heart Slice Model of Arrhythmogenic Cardiomyopathy Using Plakophilin-2 Mutant Myocytes. Adriana Blazeski, Justin Lowenthal, Yin Wang, Roald Teuben, Renjun Zhu, Sharon Gerecht, Gordon Tomaselli, Leslie Tung Tissue Eng Part A. 2019 May;25(9-10):725-735. | Engineered heart slices | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells. Andy On-Tik Wong, Gabriel Wong, Michael Shen, Maggie Zi-Ying Chow, Wan Wai Tse, Bimal Gurung, Suet Yee Mak, Deborah K Lieu, Kevin D Costa, Camie W Chan, Alain Martelli, Joseph F Nabhan, Ronald A Li Stem Cell Res Ther. 2019 Jul 8;10(1):203. | Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) | VSD (Di-8-ANEPPS) | MiCAM ULTIMA |
| Contribution of potassium channels to action potential repolarization of human embryonic stem cell-derived cardiomyocytes. Yin Wang, Renjun Zhu, Leslie Tung Br J Pharmacol. 2019 Aug;176(15):2780-2794. | Human embryonic stem cell]derived cardiomyocytes (hESC-CMs) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Enhancement of human iPSC-derived cardiomyocyte maturation by chemical conditioning in a 3D environment. Chen Yu Huang, Rebeca Peres Moreno Maia-Joca, Chin Siang Ong, Ijala Wilson, Deborah DiSilvestre, Gordon F Tomaselli, Daniel H Reich J Mol Cell Cardiol. 2020 Jan;138:1-11. | Human induced pluripotent stem-derived cardiomyocytes (hiPSC-CMs) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias. Hiroyuki Nakanishi, Jong-Kook Lee, Keiko Miwa, Kiyoshi Masuyama, Hideki Yasutake, Jun Li, Satoki Tomoyama, Yayoi Honda, Jiro Deguchi, Shinji Tsujimoto, Kyoko Hidaka, Shigeru Miyagawa, Yoshiki Sawa, Issei Komuro, Yasushi Sakata Front Physiol. 2019 Jun 27;10:818. | Human induced pluripotent stem-derived cardiomyocytes (hiPSC-CMs) | VSD (FluoVolt) | MiCAM02 |
| Multiparametric slice culture platform for the investigation of human cardiac tissue physiology. Yun Qiao, Quan Dong, Baichen Li, Sofian Obaid, Christian Miccile, Rose T Yin, Trisha Talapatra, Zexu Lin, Sihui Li, Zhenyu Li, Igor R Efimov Prog Biophys Mol Biol. 2019 Jul;144:139-150. | Cultured murine atria and human slices | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing. Anna M. D. Végh, A. Dénise Den Haan, Lucía Cócera Ortega, Arie O. Verkerk, Joost P. G. Sluijter, Diane Bakker, Shirley Van Amersfoorth, Toon A. B. Van Veen, Mischa Klerk, Jurgen Seppen, Jacques M. T. De Bakker, Vincent M. Christoffels, Dirk Geerts, Marie José T. H. Goumans, Hanno L. Tan and Gerard J. J. Boink Molecules. 2019 Jan 5;24(1). pii: E181. | Organ explant cultures | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Engineered Heart Slice Model of Arrhythmogenic Cardiomyopathy using Plakophilin-2 Mutant Myocytes. Adriana Blazeski, Justin Lowenthal, Yin Wang, Roald Teuben, Renjun ZhuProf, Sharon Gerecht, Gordon Tomaselli and Leslie Tung Tissue Eng Part A. 2018 Dec 6. | Engineered heart slices | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system. Rupamanjari Majumder, Iolanda Feola, Alexander S Teplenin, Antoine AF de Vries, Alexander V Panfilov and Daniel A Pijnappels Elife. 2018 Sep 27;7. pii: e41076. | Neonatal rat atrial cardiomyocytes | VSD (Di-4-ANBDQBS) | MiCAM ULTIMA |
| A tissue-engineered scale model of the heart ventricle. Luke A. MacQueen, Sean P. Sheehy, Christophe O. Chantre, John F. Zimmerman, Francesco S. Pasqualini, Xujie Liu, Josue A. Goss, Patrick H. Campbell, Grant M. Gonzalez, Sung-Jin Park, Andrew K. Capulli, John P. Ferrier, T. Fettah Kosar, L. Mahadevan, William T. Pu and Kevin Kit Parker Nature Biomedical Engineering (2018). Published: 23 July 2018 | Neonatal rat ventricular myocytes | CaSD (Rhod-2) | MiCAM ULTIMA |
| Multiparametric slice culture platform for the investigation of human cardiac tissue physiology. Yun Qiao, Quan Dong, Baichen Li, Sofian Obaid, Christian Miccile, Rose T. Yin, Trisha Talapatra, Zexu Lin, Sihui Li, Zhenyu Li, and Igor R. Efimov Prog Biophys Mol Biol. 2018 Jun 27. pii: S0079-6107(18)30012-9. | Cultured mouse atrial tissue and human cardiac slices | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Paradoxical Onset of Arrhythmic Waves from Depolarized Areas in Cardiac Tissue Due to Curvature-Dependent Instability. Alexander S. Teplenin, Hans Dierckx, Antoine A. F. de Vries, Daniël A. Pijnappels, and Alexander V. Panfilov Phys Rev X. 2018 Jun 26; 8(2): 021077. | Neonatal rat ventricular myocytes | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells. Ronald A.Li, Wendy Keung, Timothy J. Cashman, Peter C. Backeris, Bryce V.Johnson, Evan S.Bardot, Andy O.T. Wong, Patrick K.W. Chan, Camie W.Y. Chan, Kevin D. Costa Biomaterials. 2018 May;163:116-127 | Human ventricle-like cardiac organoid chamber | VSD (Di-8-ANEPPS) CaSD (X-rhod-1 AM) | MiCAM ULTIMA |
| Contractile force measurement of human induced pluripotent stem cell-derived cardiac cell sheet-tissue. Daisuke Sasaki, Katsuhisa Matsuura, Hiroyoshi Seta, Yuji Haraguchi, Teruo Okano, Tatsuya Shimizu PLoS One. 2018 May 23;13(5):e0198026. | Human induced pluripotent stem-derived cardiomyocytes (hiPSC-CMs) | CaSD (Fluo-8) | MiCAM ULTIMA |
| Resolving Myocardial Activation With Novel Omnipolar Electrograms. Stéphane Massé, Karl Magtibay, Nicholas Jackson, John Asta, Marjan Kusha, Boyang Zhang, Ram Balachandran, Milica Radisic, D. Curtis Deno, and Kumaraswamy Nanthakumar Circ Arrhythm Electrophysiol. 2016 Jul;9(7):e004107. doi: 10.1161/CIRCEP.116.004107. | Monolayers | CaSD (Fluo-4 AM) | MiCAM ULTIMA |
| Variability of Action Potentials Within and Among Cardiac Cell Clusters Derived from Human Embryonic Stem Cells. Renjun Zhu, Michal A. Millrod, Elias T. Zambidis, and Leslie Tung Sci Rep. 2016 Jan 5;6:18544. doi: 10.1038/srep18544. | Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing. Johan U. Lind, Travis A. Busbee, Alexander D. Valentine, Francesco S. Pasqualini, Hongyan Yuan, Moran Yadid, Sung-Jin Park, Arda Kotikian, Alexander P. Nesmith, Patrick H. Campbell, Joost J. Vlassak, Jennifer A. Lewis and Kevin K. Parker Nat Mater. 2016 Oct 24. doi: 10.1038/nmat4782. [Epub ahead of print] | Neonatal rat ventricular myocytes | VSD (RH-237) | MiCAM ULTIMA |
| Optogenetic Engineering of Atrial Cardiomyocytes. Iolanda Feola, Alexander Teplenin, Antoine A. F. de Vries, Daniël A. Pijnappels Methods Mol Biol. 2016;1408:319-31. doi: 10.1007/978-1-4939-3512-3_22. | Atrial cardiomyocytes (aCMCs) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity. Angie M. Y. Shum, Hui Che, Andy On-Tik Wong, Chenzi Zhang, Hongkai Wu, Camie W. Y. Chan, Kevin Costa, Michelle Khine, Chi-Wing Kong, Ronald A. Li Adv Mater. 2016 Nov 2. doi: 10.1002/adma.201602448. [Epub ahead of print] | Human ventricular cardiac anisotropic sheet (hvCAS) | VSD (Di-8-ANEPPS) | MiCAM ULTIMA |
| Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium Rupamanjari Majumder, Marc C. Engels, Antoine A. F. de Vries, Alexander V. Panfilov, and Daniël A. Pijnappels Sci Rep. 2016; 6: 24334. Published online 2016 Apr 13. doi: 10.1038/srep24334 | Monolayers | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Electroactive polyurethane/siloxane derived from castor oil as a versatile cardiac patch, Part II: HL-1 cytocompatibility and electrical characterizations. Nafiseh Baheiraei, Reza Gharibi, Hamid Yeganeh, Michele Miragoli, Nicolò Salvarani, Elisa Di Pasquale and Gianluigi Condorelli J Biomed Mater Res A. 2016 Jan 28. doi: 10.1002/jbm.a.35669. [Epub ahead of print] | HL-1 monolayers | CaSD (Fluo-4 AM) | MiCAM ULTIMA |
| The protective effect of ursodeoxycholic acid in an in vitro model of the human fetal heart occurs via targeting cardiac fibroblasts. Francisca Schultz, Alveera Hasan, Anita Alvarez-Laviada, Michele Miragoli, Navneet Bhogal, Sarah Wells, Claire Poulet, Jenny Chambers, Catherine Williamson and Julia Gorelik Prog Biophys Mol Biol. 2016 Jan 8. pii: S0079-6107(16)00005-5. doi: 10.1016/j.pbiomolbio.2016.01.003. [Epub ahead of print] | Isolated cardiomyocytes | CaSD (Fluo-4 AM) VSD (Di-8-ANEPPS) | MiCAM ULTIMA |
| Microtubule-Dependent Mitochondria Alignment Regulates Calcium Release in Response to Nanomechanical Stimulus in Heart Myocytes. Michele Miragoli, Jose L. Sanchez-Alonso, Anamika Bhargava, Peter T. Wright, Markus Sikkel, Sophie Schobesberger, Ivan Diakonov, Pavel Novak, Alessandra Castaldi, Paola Cattaneo, Alexander R. Lyon, Max J. Lab, Julia Gorelik Cell Rep. 2016 Jan 5;14(1):140-51. doi: 10.1016/j.celrep.2015.12.014. Epub 2015 Dec 24. | Isolated cardiomyocytes | CaSD (Fluo-4 AM) | MiCAM ULTIMA |
| Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Bo Lin, Yang Li, Lu Han, Aaron D. Kaplan, Ying Ao, Spandan Kalra, Glenna C. L. Bett, Randall L. Rasmusson, Chris Denning and Lei Yang Dis Model Mech. 2015 May;8(5):457-66. doi: 10.1242/dmm.019505. Epub 2015 Mar 19. | Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) | CaSD (Rhod-2 AM) | MiCAM ULTIMA |
| Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial Myocytes. Alexey V. Glukhov, Marina Balycheva, Jose L. Sanchez-Alonso, Zeki Ilkan, Anita Alvarez-Laviada, Navneet Bhogal, Ivan Diakonov, Sophie Schobesberger, Markus B. Sikkel, Anamika Bhargava, Giuseppe Faggian, Prakash P. Punjabi, Steven R. Houser and Julia Gorelik Circulation. 2015 Oct 8. pii: CIRCULATIONAHA.115.018131. [Epub ahead of print] | Human atrial myocytes | CaSD (Fluo-4 AM) | MiCAM ULTIMA |
| Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs. Gaopeng Chen, Sen Li, Ioannis Karakikes, Lihuan Ren, Maggie Zi-Ying Chow, Anant Chopra, Wendy Keung, Bin Yan, Camie WY Chan, Kevin D. Costa, Chi-Wing Kong, Roger J. Hajjar, Christopher S. Chen and Ronald A. Li Circ Arrhythm Electrophysiol. 2015 Feb;8(1):193-202. doi: 10.1161/CIRCEP.114.002049. Epub 2014 Dec 10. | hESC/iPSC-vCMs | CaSD (X-Rhod-1 AM) | MiCAM ULTIMA |
| Combining TGF-ƒÀ signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes Ping Dai, Yoshinori Harada, Hitoshi Miyachi, Hideo Tanaka, Satsuki Kitano, Tetsuya Adachi, Tomoyuki Suzuki, Hitoshi Hino and Tetsuro Takamatsu Sci Rep. 2014; 4: 7323. | Cardiomyocytes derived from siPSCs | CaSD (Fluo-4 AM) | MiCAM02 |
| Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes. Brian O. Bingen, Marc C. Engels, Martin J. Schalij, Wanchana Jangsangthong, Zeinab Neshati, Iolanda Feola, Dirk L. Ypey, Saïd F.A. Askar, Alexander V. Panfilov, Daniël A. Pijnappels and Antoine A.F. de Vries Cardiovasc Res. 2014 Jul 31. pii: cvu179. [Epub ahead of print] | Neonatal rat atrial cardiomyocyte monolayers | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Calcium Transients Closely Reflect Prolonged Action Potentials in iPSC Models of Inherited Cardiac Arrhythmia. C. Ian Spencer, Shiro Baba, Kenta Nakamura, Ethan A. Hua, Marie A.F. Sears, Chi-cheng Fu, Jianhua Zhang, Sadguna Balijepalli, Kiichiro Tomoda, Yohei Hayashi, Paweena Lizarraga, Julianne Wojciak, Melvin M. Scheinman, Katriina Aalto-Setälä, Jonathan C. Makielski, Craig T. January, Kevin E. Healy, Timothy J. Kamp, Shinya Yamanaka, Bruce R. Conklinemail Stem Cell Reports. 2014 Aug 12;3(2):269-281. | Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) | CaSD (Fluo-4 AM) | MiCAM02 |
| Quality metrics for stem cell-derived cardiac myocytes. Sean P. Sheehy, Francesco Pasqualini, Anna Grosberg, Sung Jin Park, Yvonne Aratyn-Schaus and Kevin Kit Parker Stem Cell Reports. 2014 Mar 6;2(3):282-94. doi: 10.1016/j.stemcr.2014.01.015. eCollection 2014. | Neonatal mouse ventricular cardiomyocytes | VSD (RH-237) | MiCAM ULTIMA |
| Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State. Weining Bian, Nima Badie, Herman D. Himel IV and Nenad Bursac Biomaterials. 2014 Apr;35(12):3819-28. doi: 10.1016/j.biomaterials.2014.01.045. Epub 2014 Feb 6. | Neonatal rat ventricular cardiomyocytes | CaSD (Rhod-2) | MiCAM ULTIMA |
| Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias. Jiaxian Wang, Aaron Chen, Deborah K. Lieu, Ioannis Karakikes, Gaopeng Chen, Wendy Keung, Camie W. Chan, Roger J. Hajjar, Kevin D. Costa, Michelle Khine and Ronald A. Li Biomaterials. 2013 Nov;34(35):8878-86. doi: 10.1016/j.biomaterials.2013.07.039. Epub 2013 Aug 12. | Human pluripotent stem cell-derived ventricular cardiomyocytes (hPSC-CMs) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State. Ji-Dong Fu, Nicole R. Stone, Lei Liu, C. Ian Spencer, Li Qian, Yohei Hayashi, Paul Delgado-Olguin, Sheng Ding, Benoit G. Bruneau and Deepak Srivastava Stem Cell Reports, Volume 1, Issue 3, 235-247, 22 August 2013 | Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) | CaSD (Fluo-4 AM) | MiCAM02 |
| CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia. Di Pasquale E, Lodola F, Miragoli M, Denegri M, Avelino-Cruz JE, Buonocore M, Nakahama H, Portararo P, Bloise R, Napolitano C, Condorelli G and Priori SG Cell Death Dis. 2013 Oct 10;4:e843. doi: 10.1038/cddis.2013.369. | iPSC-derived cardiac cells | CaSD (Fluo-4 AM) | MiCAM ULTIMA |
| Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells. Tung-Ying Lu, Bo Lin, Jong Kim, Mara Sullivan, Kimimasa Tobita, Guy Salama and Lei Yang Nat Commun. 2013 Aug 14;4:2307. doi: 10.1038/ncomms3307. | Human induced pluripotent stem cell-derived cardiovascular progenitor cells | CaSD (Rhod-2) | MiCAM ULTIMA |
| Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Sara S Nunes, Jason W Miklas, Jie Liu, Roozbeh Aschar-Sobbi, Yun Xiao, Boyang Zhang, Jiahua Jiang, Stéphane Massé, Mark Gagliardi, Anne Hsieh, Nimalan Thavandiran, Michael A Laflamme, Kumaraswamy Nanthakumar, Gil J Gross, Peter H Backx, Gordon Keller and Milica Radisic Nat Methods. 2013 Aug;10(8):781-7. doi: 10.1038/nmeth.2524. Epub 2013 Jun 23. | Human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Fibroblast KATP Currents Modulate Myocyte Electrophysiology in Infarcted Hearts. Najate Benamer, Carolina Vasquez, Vanessa M Mahoney, Maximilian J Steinhardt, William A Coetzee, and Gregory E Morley Am J Physiol Heart Circ Physiol. 2013 May;304(9):H1231-9. doi: 10.1152/ajpheart.00878.2012. Epub 2013 Feb 22. | Monolayer | VSD (Di-8-ANEPPS) | MiCAM ULTIMA |
| Oscillation in Cycle Length Induces Transient Discordant and Steady-State Concordant Alternans in the Heart. Seth H. Weinberg and Leslie Tung PLoS One. 2012;7(7):e40477. Epub 2012 Jul 5. | Monolayer | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| ILK Induces Cardiomyogenesis in the Human Heart. Alexandra Traister, Shabana Aafaqi, Stephane Masse, Xiaojing Dai, Mark Li, Aleksander Hinek, Kumaraswamy Nanthakumar, Gregory Hannigan and John G. Coles Med Image Anal. 2012 Feb;16(2):505-23. Epub 2011 Dec 6. | Human fetal cardiomyocytes | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Functional Scaffold-Free 3D Cardiac Microtissues: a Novel Model for the Investigation of Heart Cells. Bethany R Desroches, Peng Zhang, Bum-Rak Choi, Michelle E King, Angel E Maldonado, Weiyan Li, Adam Rago, Gong-Xin Liu, Nandan Nath, Kathryn M Hartmann, Bryant Yang, Gideon Koren, Jeffrey R Morgan and Ulrike Mende Am J Physiol Heart Circ Physiol. 2012 Mar 16. [Epub ahead of print] | Neonatal rat cardiomyocytes | VSD (RH-237) | MiCAM ULTIMA |
| High-purity enrichment of functional cardiovascular cells from human iPS cells. Bo Lin, Jong Kim, Yanxin Li, Haiying Pan, Xonia Carvajal-Vergara, Guy Salama, Tao Cheng, Yong Li, Cecilia W. Lo and Lei Yang Cardiovasc Res. 2012 Aug 1;95(3):327-35. Epub 2012 Jun 6. | Human iPSC-derived cardiovascular cells | CaSD (Rhod-2) | MiCAM ULTIMA |
| Connexin43 silencing in myofibroblasts prevents arrhythmias in myocardial cultures: role of maximal diastolic potential. Saïd F. Askar, Brian O. Bingen, Jim Swildens, Dirk L. Ypey, Arnoud van der Laarse, Douwe E. Atsma, Katja Zeppenfeld, Martin J. Schalij, Antoine A. de Vries and Daniël A. Pijnappels Cardiovasc Res. 2012 Mar 1;93(3):434-44. Epub 2011 Dec 22. | Primary ventricular cardiomyocytes | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. Aaron Chen, Deborah K. Lieu, Lauren Freschauf, Valerie Lew, Himanshu Sharma, Jiaxian Wang, Diep Nguyen, Ioannis Karakikes, Roger J. Hajjar, Ajay Gopinathan, Elliot Botvinick, Charless C. Fowlkes, Ronald A. Li and Michelle Khine Adv Mater. 2011 Dec 22;23(48):5785-91. doi: 10.1002/adma.201103463. Epub 2011 Nov 8. | Human embryonic stem cells-derived cardiomyocytes (hESC-CMs) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Human embryonic and fetal mesenchymal stem cells differentiate toward three different cardiac lineages in contrast to their adult counterparts. Arti A. Ramkisoensing, Daniël A. Pijnappels, Saïd F. A. Askar, Robert Passier, Jim Swildens, Marie José Goumans, Cindy I. Schutte, Antoine A. F. de Vries, Sicco Scherjon, Christine L. Mummery, Martin J. Schalij and Douwe E. Atsma PLoS One. 2011;6(9):e24164. Epub 2011 Sep 9. | Neonatal rat ventricular cardiomyocytes | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart. Michele Miragoli, Siti H. Sheikh Abdul Kadir, Mary N. Sheppard, Nicoló Salvarani, Matilda Virta, Sarah Wells, Max J. Lab, Viacheslav O. Nikolaev, Alexey Moshkov, William M. Hague, Stephan Rohr, Catherine Williamson and Julia Gorelik Hepatology. 2011 Oct;54(4):1282-92. doi: 10.1002/hep.24492. Epub 2011 Aug 1. | Monolayer | VSD (Di-8-ANEPPS) | MiCAM ULTIMA |
| Antiproliferative treatment of myofibroblasts prevents arrhythmias in vitro by limiting myofibroblast-induced depolarization. Saïd F.A. Askar, Arti A. Ramkisoensing, Martin J. Schalij, Brian O. Bingen, Jim Swildens, Arnoud van der Laarse, Douwe E. Atsma, Antoine A.F. de Vries, Dirk L. Ypey and Daniël A. Pijnappels Cardiovasc Res. 2011 Feb 2. [Epub ahead of print] | Neonatal rat ventricular cardiomyocytes | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Enhanced fibroblast-myocyte interactions in response to cardiac injury. Carolina Vasquez, Poornima Mohandas, Karen L. Louie, Najate Benamer, Ashwini C. Bapat and Gregory E. Morley Circ Res. 2010 Oct 15;107(8):1011-20. Epub 2010 Aug 12. | Monolayer | VSD (Di-8-ANEPPS) | MiCAM ULTIMA |
| Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Masaki Ieda, Ji-Dong Fu, Paul Delgado-Olguin, Vasanth Vedantham, Yohei Hayashi, Benoit G. Bruneau and Deepak Srivastava Cell. 2010 Aug 6;142(3):375-86. | Cardiac fibroblast?derived induced cardiomyocytes | CaSD (Rhod-3) | MiCAM02 |
| Bile Acid-Induced Arrhythmia Is Mediated by Muscarinic M2 Receptors in Neonatal Rat Cardiomyocytes. Siti H. Sheikh Abdul Kadir, Michele Miragoli, Shadi Abu-Hayyeh, Alexey V. Moshkov, Qilian Xie, Verna Keitel, Viacheslav O. Nikolaev, Catherine Williamson and Julia Gorelik PLoS One. 2010; 5(3): e9689. | Ventricular neonatal rat myocyte | CaSD (Fluo-4 AM) | MiCAM ULTIMA |
| Engineered heart tissue: a novel tool to study the ischemic changes of the heart in vitro. Rajesh G. Katare, Motonori Ando, Yoshihiko Kakinuma and Takayuki Sato PLoS One. 2010 Feb 17;5(2):e9275. | Engineered heart tissue | VSD (Di-4-ANEPPS) | MiCAM02 |
| Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue. Hannah Song, Charles Yoon, Steven J. Kattman, Jana Dengler, Stéphane Massé, Thushaanthini Thavaratnam, Mena Gewarges, Kumaraswamy Nanthakumar, Michael Rubart, Gordon M. Keller, Milica Radisic and Peter W. Zandstra Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3329-34. | Engineered heart tissue | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Electrogram fractionation in murine HL-1 atrial monolayer model. Karthikeyan Umapathy, Stephane Masse, Karolina Kolodziejska, George D. Veenhuyzen, Vijay S. Chauhan, Mansoor Husain, Talha Farid, Eugene Downar, Elias Sevaptsidis and Kumaraswamy Nanthakumar Heart Rhythm. 2008 Jul;5(7):1029-35. | Monolayer (HL-1) | VSD (Di-4-ANEPPS) | MiCAM ULTIMA |
| Generation of reentrant arrhythmias by dominant-negative inhibition of connexin43 in rat cultured myocyte monolayers Takuo Nakagami, Hideo Tanaka, Ping Dai, Shien-Fong Lin, Takuji Tanabe, Hiroki Mani, Katsuji Fujiwara, Hiroaki Matsubara and Tetsuro Takamatsu Cardiovasc Res. 2008 Jul 1;79(1):70-9. Epub 2008 Mar 31. | Monolayer | CaSD (Fluo-4) | MiCAM02 |
| Myofibroblasts induce ectopic activity in cardiac tissue. Michele Miragoli, Nicolò Salvarani and Stephan Rohr Circ Res. 2007 Oct 12;101(8):755-8. | Monolayer | VSD (Di-8-ANEPPS) | MiCAM ULTIMA |
| Dynamic changes of cardiac conduction during rapid pacing. Aleksandar A. Kondratyev, Julien G. C. Ponard, Adelina Munteanu, Stephan Rohr and Jan P. Kucera Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1796-1811. | Monolayer | VSD (Di-8-ANEPPS) | MiCAM ULTIMA |
| A new method for manufacturing cardiac cell sheets using fibrin-coated dishes and its electrophysiological studies by optical mapping. Yuji Itabashi, Shunichiro Miyoshi, Haruko Kawaguchi, Shinsuke Yuasa, Kojiro Tanimoto, Akira Furuta, Tatsuya Shimizu, Teruo Okano, Keiichi Fukuda and Satoshi Ogawa Artif Organs. 2005 Feb;29(2):95-103. | Myocardial cell sheets | VSD (Di-4-ANEPPS) | MiCAM01 |
